ABSTRACT
A 12-year-old boy was tackled mid-air, resulting in a fall on the outstretched hand without fracture. The patient was treated conservatively but developed sharp pain and stiffness 6 months later. Imaging revealed distal radius avascular necrosis with physeal involvement. Owing to the injury chronicity and location, we treated the patient conservatively with hand therapy. After 1 year of therapy, the patient returned to normal activities without pain and with a resolution of findings on imaging. Avascular necrosis is more frequent in carpal bones (eg, Kienböck disease of the lunate and Preiser disease of the scaphoid). Growth arrest at the distal radius can lead to ulnocarpal impaction, triangular fibrocartilage complex injury, or distal radioulnar joint injury. In this case report, we discuss our treatment rationale and review the literature on pediatric avascular necrosis for hand surgeons.
ABSTRACT
The use of Raman spectroscopy to analyze the biochemical composition of serum samples and hence distinguish between normal and cervical cancer serum samples was investigated. The serum samples were obtained from 19 patients who were clinically diagnosed with cervical cancer, 3 precancer, and 20 healthy volunteer controls. The imprint was put under an Olympus microscope, and around points were chosen for Raman measurement.All spectra were collected at a Horiba Jobin-Yvon LabRAM HR800 Raman Spectrometer with a laser of 830-nm wavelength and 17-mW power irradiation. Raw spectra were processed by carrying out baseline correction, smoothing, and normalization to remove noise, florescence, and shot noise and then analyzed using principal component analysis (PCA). The control serum spectrum showed the presence of higher amounts of carotenoids indicated by peaks at 1,002, 1,160, and 1,523 cm(-1)and intense peaks associated with protein components at 754, 853, 938, 1,002, 1,300-1,345, 1,447, 1,523, 1,550, 1,620, and 1,654 cm(-1). The Raman bands assigned to glutathione (446, 828, and 1,404 cm(-1)) and tryptophan (509, 1,208, 1,556, 1,603, and 1,620 cm(-1)) in cervical cancer were higher than those of control samples, suggesting that their presence may also play a role in cervical cancer. Furthermore, weak bands in the control samples attributed to tryptophan (545, 760, and 1,174 cm(-1)) and amide III (1,234-1,290 cm(-1)) seem to disappear and decrease in the cervical cancer samples, respectively. It is shown that the serum samples from patients with cervical cancer and from the control group can be discriminated with high sensitivity and specificity when the multivariate statistical methods of PCA is applied to Raman spectra. PCA allowed us to define the wavelength differences between the spectral bands of the control and cervical cancer groups by confirming that the main molecular differences among the control and cervical cancer samples were glutathione, tryptophan, ß carotene, and amide III. The preliminary results suggest that Raman spectroscopy could be a highly effective technique with a strong potential of support for current techniques as Papanicolaou smear by reducing the number of these tests; nevertheless, with the construction of a data library integrated with a large number of cervical cancer and control Raman spectra obtained from a wide range of healthy and cervical cancer population, Raman-PCA technique could be converted into a new technique for noninvasive real-time diagnosis of cervical cancer from serum samples.
Subject(s)
Spectrum Analysis, Raman/methods , Uterine Cervical Neoplasms/blood , Uterine Cervical Neoplasms/diagnosis , Adult , Female , Humans , Middle Aged , Principal Component Analysis , Sensitivity and Specificity , Young AdultABSTRACT
In this work, we report the physicochemical properties of a variety of aliphatic phosphonium iodide (API) salts, including thermal degradation. Also, we compared the conductivity, viscosity, and fragility behavior of APIs to similar molten systems and related these properties to their structure. Our investigation has found that APIs have an intermediate fragility behavior. We plotted the conductivity and viscosity data of APIs according to Walden's rule and found that they can be classified as an associated ionic liquid (AIL), an intermediate between a true ionic liquid and a molecular species. Lastly, we correlated the structure and behavior of APIs and similar polarizable anions, such as the diacetamide anion.
ABSTRACT
La Miastenia Gravis es una enfermedad neuromuscular caracterizada por debilidad muscular y fatiga debida a la reducción de los receptores de acetil colina en la unión neuromuscular, la cuasa es una reacción autoinmune que depende probablemente de la lisis, dependiente del complemento, de la membrana postsináptica y un aumento de la degradación de los receptores de acetil colina.
