ABSTRACT
Metformin is an antihyperglycemic agent commonly used in diabetic patients. It is very effective and is able to reduce the plasma glucose and HbA1C. However, in some patients, specially those with comorbidities, metformin can provoke severe lactic acidosis with high morbimortality. Treatment of the lactic acidosis induced by metformin is based on the use of supportive general measures; in severe cases, procedures of extrarrenal purification like hemodialysis or continuous hemodiafiltration have been successfully used.
Subject(s)
Acidosis, Lactic/chemically induced , Hypoglycemic Agents/adverse effects , Metformin/adverse effects , Nephrology , Physician's Role , Acute Kidney Injury/complications , Aged , Aged, 80 and over , Angiotensin-Converting Enzyme Inhibitors/adverse effects , Angiotensin-Converting Enzyme Inhibitors/pharmacology , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Antidepressive Agents/therapeutic use , Cardiovascular Agents/administration & dosage , Cardiovascular Agents/adverse effects , Cardiovascular Agents/therapeutic use , Cardiovascular Diseases/complications , Cardiovascular Diseases/drug therapy , Coma/chemically induced , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/drug therapy , Drug Synergism , Drug Therapy, Combination , Emergencies , Fatal Outcome , Female , Humans , Hypoglycemic Agents/administration & dosage , Hypoglycemic Agents/therapeutic use , Ibuprofen/adverse effects , Ibuprofen/pharmacology , Ibuprofen/therapeutic use , Male , Metformin/administration & dosage , Metformin/therapeutic use , Middle Aged , PolypharmacyABSTRACT
La metformina es un fármaco ampliamente utilizado en sujetos con diabetes mellitus y su eficacia para descender la glucemia y la hemoglobina A1C (HbA1C) es notable. Sin embargo, en algunos pacientes, sobre todo en los que presentan comorbilidades, puede provocar una acidosis láctica grave que origina una elevada morbimortalidad. El tratamiento de esta complicación se basa en la utilización de medidas de soporte y, en los casos más graves, en procedimientos de depuración extrarrenal, como la hemodiálisis o la hemodiafiltración continua (AU)
Metformin is an antihyperglycemic agent commonly used in diabetic patients. It is very effective and is able to reduce the plasma glucose and HbA1C. However, in some patients, specially those with comorbidities, metformin can provoke severe lactic acidosis with high morbimortality. Treatment of the lactic acidosis induced by metformin is based on the use of supportive general measures; in severe cases, procedures of extrarrenal purification like hemodialysis or continuous hemodiafiltration have been successfully used (AU)
Subject(s)
Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Acidosis, Lactic/chemically induced , Metformin/adverse effects , Renal Dialysis/methods , Hemofiltration/methods , Diabetes Mellitus/drug therapy , Risk FactorsABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Methanol/poisoning , Poisoning/therapy , Renal Dialysis , Toluene/poisoning , Ketosis/etiologySubject(s)
Methanol/poisoning , Renal Dialysis , Acute Disease , Adult , Humans , Male , Poisoning/therapy , Renal Dialysis/methods , Time FactorsSubject(s)
Chylothorax/etiology , Pleural Effusion/complications , Renal Dialysis , Aged , Female , HumansABSTRACT
No disponible
No disponible
