ABSTRACT
In Mexico, the generic drug market is growing. Regarding topical corticosteroids, there are several preparations on the local market but their clinical efficacy has not been assessed in relation with the original brand name. Using as a model the fluocinolone acetonide cream, the purpose of this study was to evaluate the antiinflammatory effect of different preparations. A double-blind, vehicle-control essay was conducted causing irritation on five sites of the volar aspect of the forearm in twenty healthy volunteers using 10% aqueous sodium lauryl sulfate. On the same part of the forearm, the formulations tested were applied for a period of 4 days with visual score irritation readings at days 2 and 4. The analysis of the results showed that although one of the generic drugs is 80% less expensive than the brandname medication, the clinical response was not as good as the other preparations. This deserves consideration, as newer and more potent generic corticosteroids will be available on the Mexican market.
Subject(s)
Anti-Inflammatory Agents/therapeutic use , Dermatitis/drug therapy , Drugs, Generic/therapeutic use , Fluocinolone Acetonide/therapeutic use , Administration, Topical , Adult , Double-Blind Method , Female , Glucocorticoids , Humans , Male , Middle AgedSubject(s)
Candidiasis, Vulvovaginal/diagnosis , Trichomonas Vaginitis/diagnosis , Adolescent , Adult , Aged , Candida albicans/isolation & purification , Candidiasis, Vulvovaginal/microbiology , Diagnostic Errors , Female , Humans , Microbiological Techniques , Middle Aged , Trichomonas vaginalis/isolation & purification , Vaginal SmearsABSTRACT
Con el proposito de afinar el proceso diagnostico en las vaginitis se investigo la frecuencia con la que se aislan las diferentes especies de Candida en nuestro medio. Se hicieron tomas de exudado vaginal en 180 pacientes de consulta externa en las que, ademas, se busco la presencia de Trichomonas vaginalis. La especiacion de Candida se llevo a cabo mediante morfologia cultural, fermentacion de azucares, busqueda de clamidosporas y produccion de tubos germinales en suero. Un 32 por ciento de las pacientes dieron lugar a hallazgos significativos, con 16 casos de tricomoniasis y 44 con candidas patogenas. Ademas de C. albicans y C. stellatoidea, se encontraron cinco cepas de C. Krusei, una de C. parakrusei y una de C. tropicalis.Se demostro un considerable porcentaje de error (aproximadamente 50 por ciento) al formular diagnostico de "tricomoniasis" o "candidiasis" desde el punto de vista clinico. Hubo una buena correlacion entre la presencia de seudohifas en el exudado y la identificacion posterior de C. albicans.Se sugiere que la ausencia de leucocitos permite excluir el diagnostico de tricomoniasis
Subject(s)
Adolescent , Adult , Middle Aged , Humans , Female , Candidiasis , Trichomonas Infections , Vaginitis , Diagnosis, Differential , Trichomonas vaginalisABSTRACT
Two methods for collecting fecal specimens for parasitologic examination were compared: the usual samples from different days to be studied separately ("triads") and the alternate procedure of mixing three daily specimens in a single flask with thimerosal-iodine-formaldehyde as preservative ("blend"), in order to save time and effort on the part of the microscopist. Stool samples totalling 284 from 71 heavily parasitized persons were examined. No significant difference was found in the results of studying "triads" and "blends" by two concentration technics.