ABSTRACT
We studied possible cardiovascular effects (systolic, diastolic, mean arterial blood pressures, and heart rate) caused by intraoral infiltrative administration of 2% mepivacaine HCl with 1:20,000 levonordefrin in dogs (Canis familiaris), using a Beckman electrophysiograph. Doses used were 0.514 and 1.542 mg/kg body weight corresponding to one and three 1.8-ml cartridges, respectively, in 70-kg average weight adult men. A statistically significant increase was observed in the systolic and the mean arterial blood pressures.
Subject(s)
Anesthetics, Local/pharmacology , Cardiovascular System/drug effects , Mepivacaine/pharmacology , Nordefrin/pharmacology , Vasoconstrictor Agents/pharmacology , Animals , Blood Pressure/drug effects , Dogs , Dose-Response Relationship, Drug , Drug Combinations , Female , Heart Rate/drug effects , Male , Systole/drug effects , Time FactorsABSTRACT
The effect of periodic amputations of the lower incisors of the rat on the electrolyte concentration in the major salivary glands was studied. The incisor amputations caused a hypertrophy of the parotid, submandibular and sublingual glands. The resulting increased weight of the salivary glands was due to a higher dry mass. In general, the electrolyte concentration showed higher values in the salivary gland tissues of the incisor-amputated animals. Considering the parotid, submandibular and sublingual glands respectively, the Na+ concentration was increased by 47%, 50% and 14%; and Mg2+ concentration by 377%, 126+ and 376%. Inorganic phosphorus increased 45% in the parotid, 25% in the subnamdibular and was unchanged in the sublingual gland. K+ concentration increased in the submandibular (12%) and sublingual (100%) glands but decreased in the parotid (24%). The Na+/k+ ratio was higher in the parotid (82%) and submandibular (37%) glands and lower in the sublingual gland (84%). The electrolyte concen-ration changes are discussed in relation to the mechanism and type of stimulation promoted by the incisor-amputations on the major salivary glands of the rat.
