Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 6 de 6
Filter
Add more filters










Database
Publication year range
1.
Int J Immunopathol Pharmacol ; 17(2 Suppl): 115-22, 2004.
Article in English | MEDLINE | ID: mdl-15345202

ABSTRACT

Exposure to Ti compounds is today an occupational and environmental health hazard. Object of this study was to determine "in vitro" effects of different Ti salts on cultured human peripheral blood mononuclear cells (PBMC) proliferation and cytokine release. 10(-4) and 10(-7) M Ti compounds did not modify spontaneous PBMC proliferation. Ti dioxide (a biocompatible material and sunscreen component) did not exert effects on phytoemagglutinin (PHA) stimulated PBMC proliferation and on PHA stimulated IFN-gamma and TNF-alpha release from PBMC. On the other hand, 10(-4) M Ti oxalate (with wide industrial applications) and Ti ascorbate (used mainly in agriculture) inhibited about 70% the PHA stimulate PBMC proliferation; both these Ti compounds at 10(-4) and 10(-7) M concentrations significantly inhibited TNF-alpha release, while only Ti oxalate inhibited that of IFN-gamma. Titanocene (used in chemotherapy) did no exert effects on PBMC proliferation but markedly inhibited IFN-gamma and TNF-alpha release. On the whole, this study demonstrates that Ti dioxide is not immunotoxic; Ti oxalate shows marked immunotoxicity; titanocene exerts selective toxicity on cytokine release but not on PBMC proliferation, while Ti ascorbate affects TNF-alpha release from PBMC but not iFN-gamma release. In conclusion, the data show that immunotoxicity fo Ti depends on speciation.


Subject(s)
Leukocytes, Mononuclear/drug effects , Leukocytes, Mononuclear/immunology , Titanium , Adult , Agriculture , Cell Proliferation/drug effects , Cells, Cultured , Humans , Male , Middle Aged , Occupational Diseases/immunology , Occupational Exposure/adverse effects , Titanium/toxicity
2.
G Ital Med Lav Ergon ; 25 Suppl(3): 71-2, 2003.
Article in Italian | MEDLINE | ID: mdl-14979089

ABSTRACT

The "in vitro" immune effects of K2TeO3xH2O (Te IV) and K2TeO4x2H2O (Te VI) on peripheral blood mononuclear cells (PBMC) was determined. Te(IV) inhibited PBMC proliferation and IFN-gamma, IL-5 and TNF-alpha release from PBMC more than Te (VI).


Subject(s)
Immune System/drug effects , Leukocytes, Mononuclear/drug effects , Tellurium/toxicity , Humans , Leukocytes, Mononuclear/immunology
3.
G Ital Med Lav Ergon ; 25 Suppl(3): 69-70, 2003.
Article in Italian | MEDLINE | ID: mdl-14979088

ABSTRACT

The "in vitro" immune effects of different Ti compounds on peripheral blood mononuclear cells (PBMC) were determined. The results show that Ti dioxide is not immunotoxic; Ti oxalate is strongly immunotoxic; titanocene inhibits cytokine release but not PBMC proliferation, while Ti ascorbate inhibits TNF-alpha release from PBMC but not that of IFN-gamma. The results show that Ti toxicity depends on speciation.


Subject(s)
Immune System/drug effects , Leukocytes, Mononuclear/drug effects , Titanium/toxicity , Dose-Response Relationship, Drug , Humans , Leukocytes, Mononuclear/immunology
4.
G Ital Med Lav Ergon ; 25 Suppl(3): 144-5, 2003.
Article in Italian | MEDLINE | ID: mdl-14979122

ABSTRACT

Tryptase is a protein released by mast cells, which is involved in the enhancement of inflammatory sequences in immune-mediated reactions. According with our experience, some patients having a reaction clinically classified as anaphylaxis, showed high levels of tryptase (> 20 ng/l) but also of serum specific IgE, showing the immune-mediated nature of the reactions. On the other hand workers without specific IgE and with low levels of tryptase probably had developed pseudoallergic (anaphylactoid) reactions. So, tryptase can be used as biomarker of occupational anaphylaxis and appear to be able to make out immune and nonimmune mediated reactions.


Subject(s)
Anaphylaxis/blood , Occupational Diseases/blood , Serine Endopeptidases/blood , Female , Humans , Male , Tryptases
5.
G Ital Med Lav Ergon ; 25 Suppl(3): 146-7, 2003.
Article in Italian | MEDLINE | ID: mdl-14979123

ABSTRACT

We studied in a group of 53 asthmatic farmers the influence of various treatment regimens on progression of disease, during five years follow-up. Specific immuno-therapy (SIT) and steroid treated patients showed significantly lower ECP levels and higher methacholine PD20 FEV1 than untreated patients, during all years of the study. During the first two years, spring ECP increase was higher in SIT treated patients than in steroid ones, however no significant differences were found during the following years. Bronchial hyperreactivity showed same course, except for a significant higher PD20 FEV1 in steroid and SIT treated asthmatics, in respect to the steroid or SIT alone. We may conclude that ECP and bronchial reactivity are useful for asthma monitoring and SIT and inhalant steroids have additional effects on asthma.


Subject(s)
Agriculture , Asthma/etiology , Bronchial Hyperreactivity/etiology , Bronchitis/etiology , Occupational Diseases/etiology , Adult , Asthma/immunology , Asthma/physiopathology , Bronchial Hyperreactivity/immunology , Bronchitis/immunology , Disease Progression , Follow-Up Studies , Humans , Middle Aged , Occupational Diseases/immunology , Poaceae/immunology , Time Factors
6.
G Ital Med Lav Ergon ; 23(4): 438-41, 2001.
Article in Italian | MEDLINE | ID: mdl-11758147

ABSTRACT

Women with a mean age of 38 years (range 20-62) were employed in an industry producing clothes of high fashion. A part of them (n = 210) performed their activities with hands and others (n = 90) utilising machines with more repetitive procedures. All the recruited women answered to a questionnaire including the state-trait anxiety inventory (STAI) test, working activities, lifestyle and obstetric history. There was no relation between obstetric history and working activities. The group of women with age ranging from 35 to 42 years showed the score of the STAI higher than that of the younger women and slightly lower than that of the subjects with older age. This may depend on the "healthy worker effect" in the old subjects able to continue their job. The scores of the STAI were also slightly influenced by the repetitive tasks utilising machines. On the whole, the working activity of women had beneficial effect on their role inside the family and in the social life.


Subject(s)
Anxiety/epidemiology , Clothing , Life Style , Reproductive History , Adult , Affect , Anxiety/blood , Dust/analysis , Family Characteristics , Female , Humans , Maternal Exposure , Menopause/blood , Middle Aged , Occupational Exposure/analysis , Posture , Test Anxiety Scale
SELECTION OF CITATIONS
SEARCH DETAIL
...