ABSTRACT
A number of 20,000 children representing 91.19% of all the enlisted children aged 6-14 years were examined. The clinical status of each child was assessed according to the WHO criteria. Goiter was found in 3,363 (16.81%) children. Of these, 1504 (44.72%) were boys and the zero degree, 2,137 (63.54%) to the 1 degree and 84 (2.49%) to the 2nd degree. As related to the total number of children examined, the zero degree goiter was found in 5.71%, the ist degree in 10.68% and the 2nd degree in 0.42% of the cases. The incidence of goiter in rural and urban areas was in the range of 6.80%-38.46%. Only in 2 areas the incidence was higher: 42.33% and 60%. A predominantly increased incidence was found in those areas which were not screened in 1951 and consequently prophylaxis was not constantly applied.
Subject(s)
Goiter, Endemic/epidemiology , Adolescent , Child , Female , Humans , Male , Mass Screening , Romania , Rural Population , Sex Factors , Urban PopulationABSTRACT
In order to study the role of myocardial hypertrophy and of the intramural tension as determinants of the increased voltage in concentric left ventricular hypertrophy, the amplitude of intracellular action potentials in frog and rat myocardium and of monophasic action potentials recorded in dogs by suction electrodes were studied. Increased amplitudes of intracellular action potentials were seen neither in experimental LVH in rats nor during stretch in frog and rat myocardium. The increased intramural tension in dog heart during norepinephrine perfusion or in heart-lung preparation during increased peripheral resistance does not increase the amplitude of monophasic action potentials. The abrupt hypertension induced by norepinephrine is an inadequate model for the study of the effect of increased intramural tension. The increase of the voltage in LVH cannot be accounted for by the increase of action potentials of each hypertrophied fibre. Many factors cooperate in producing increased voltage of LV in LVH.
Subject(s)
Cardiomegaly/physiopathology , Heart/physiopathology , Hypertension/physiopathology , Myocardial Contraction , Animals , Anura , Biomechanical Phenomena , Dogs , Electrocardiography , In Vitro Techniques , Membrane Potentials , Norepinephrine , Papillary Muscles/physiopathology , RatsABSTRACT
The authors have determined the neuro-muscular functional parameters of conductibility and excitability in normal and hyperthyroidized rats. The determination of hyperthyroidization and of the neuro-muscular functional parameters was accomplished by utilizing an own experimental model. The data obtained in rats were compared with those established by authors in normals and in patients suffering from hyperthyroidism. It resulted clearly that in rats hyperthyroidization disturbs particularly the conductibility of motor fibres while in man hyperthyroidism modified especially the excitability of motor fibres.
Subject(s)
Hyperthyroidism/physiopathology , Peroneal Nerve/physiopathology , Sciatic Nerve/physiopathology , Animals , Disease Models, Animal , Electric Stimulation , Humans , Male , Neural Conduction , RatsABSTRACT
The authors carried out a clinical, chemical and medico-social study of an endemic focus in the Arges Valley. Iodine deficiency and partially water hardness constitute the main goitrogenic factors. Owing to the curative-prophylactic means, the goitre frequency substantially decreased in school children (from 98.5% in 1949 to 18.3% in 1969) and serious forms of the third degree did not occur in the last 14 years. A certain percentage of diffuse goitre still remains in school children besides the residual pathology before the iodized prophylaxis. In the period when the prophylaxis with KI (potassium iodine) troches was neglected, a slight increase of goitre frequency was found in the investigated groups.
