ABSTRACT
In this study, a novel Benzil Bis-Hydrazone (BBH) sensor with two C = N-N = C moieties was designed and synthesized based on the condensation reaction between benzil-dihydrazone (b) and cinnamaldehyde. The BBH probe in dimethylsulfoxide showed extremely weak fluorescence. However, the same solution exhibited an intensive fluorescence enhancement (152-fold) with the introduction of Zn(II) ions. In contrast, no or negligible fluorescence changes were observed when other ions were added. The fluorogenic behavior of BBH towards the examined cations indicated an excellent selectivity of the BBH sensor for Zn(II) cations without any interference from other cations like Fe(II), Mg(II), Cu(II), Co(II), Mn(II), Cr(III), Hg(II), Sn(II), Al(I), La(III), Ca(II), Ba(II), Na(I), K(I), and especially Cd(II). Moreover, the UV-vis spectrophotometric titrations revealed that a 1:1 stoichiometric complex BBH-Zn(II) was formed during the Zn(II) sensing and the binding constant value for this complex was calculated to be equal to 106.8. Further, in order to show the affinity of the BBH sensor for Zn(II) cations, it was deemed necessary to determine the limit of detection (LOD) which was found to equal to 2.5 10-4 M.
ABSTRACT
Despite advances in vascular surgical techniques and antimicrobial therapy, aortic graft infection remains a difficult clinical problem to manage. We report a case of secondary paraprosthetic fistula. All complementary investigations were negative and the fistula was diagnosed by laparotomy. In situ replacement of the infected graft was decided despite signs of infection. The postoperative course was complicated by septic shock, successfully treated by organism-specific antibiotic therapy. In conclusion, complementary investigations should not delay laparotomy in patients with a aortic prosthesis presenting with unexplained infection. They must be considered to be suffering from a graft infection until proven otherwise. Conditions in situ replacement of the graft appears to be possible under these.
Subject(s)
Bacterial Infections/etiology , Heart Valve Prosthesis/adverse effects , Shock, Septic/etiology , Surgical Wound Infection/diagnosis , Aortic Valve/surgery , Bacterial Infections/diagnosis , Bacterial Infections/therapy , Humans , Male , Middle Aged , Shock, Septic/diagnosis , Shock, Septic/therapy , Surgical Wound Infection/therapyABSTRACT
The authors analyse a series of 100 arterial lesions in respect to the localization, the time elapsed between the accident and reconstructive surgery, and the number of associated lesions (two or more). The results confirm the prognostic importance of the factor time: 83% of the good results are obtained in the first twelve hours, and only 67.5% after twelve hours. The results seen with popliteal and tibial lesions show a steady improvement from a 50% amputation rate twenty years ago to a 21.6% rate at the present time. The presence of associated lesions is equally important in the outcome: isolated arterial lesions (or accompanied by no more than two other anomalies) are successfully treated in 91% of the patients, opposed to 50% when loco-regional lesions are found (bone, skin, veins, nerves, muscles). The optional treatment of these complex traumatisms should be by means of a multidisciplinary approach.
Subject(s)
Arteries/injuries , Wounds and Injuries/complications , Adult , Arteries/surgery , Evaluation Studies as Topic , Humans , Male , Postoperative Complications , Prognosis , Time Factors , Wounds and Injuries/surgeryABSTRACT
Results of dorsal sympathectomy in patients (67 operations) for vasomotor disorders of the upper limbs were assessed after follow-up for between 6 months and 15 years, in order to determine the best indications for surgery. Based on clinical results, sympathectomy should be performed not only when medical treatment fails, but also in the presence of a severe clinical picture of trophic disturbances or pain of the ischemic type. Two types of investigation are essential before deciding on operative therapy:--plethysmography with a hyperemia test,--arteriography of the hand. Assessment of results as a function of etiology demonstrated that they were excellent in cases of hyperhidrosis, very satisfactory in atheromatous digital arteritis or a thoracic inlet syndrome (associated with rib resection in the latter case), but only moderately good in scleroderma or post-traumatic lesions. Finally, Raynaud's disease or thromboangiitis do not appear to be indications for this operative procedure.
