ABSTRACT
Four cases of human dermatophilosis observed in Rio de Janeiro, Brazil, are reported. Data that suggest nail infection by Dermatophilus congolensis are presented. The clinical spectrum of the disease ranged from an asymptomatic infection to a pustular eruption. Our findings suggest that epidermal Langerhans cells play a role in the pathogenesis of the infection.
Subject(s)
Actinomycetales Infections/pathology , Keratinocytes/pathology , Langerhans Cells/pathology , Skin Diseases, Bacterial/pathology , Actinomycetales Infections/microbiology , Adult , Female , Humans , Male , Microscopy, Electron , Middle Aged , Skin Diseases, Bacterial/microbiologyABSTRACT
An extensive and severe actinomycetoma by Nocardia asteroides, a rare etiologic agent of this infection in Brazil, observed during a 9 year follow-up is reported. Unsuitable social and financial conditions led to amputation as the only possible solution for this case, no signs of infection relapse having been observed in three years after his surgery.
Subject(s)
Foot Dermatoses/pathology , Nocardia Infections/pathology , Nocardia asteroides , Adult , Amputation, Surgical , Brazil , Follow-Up Studies , Foot Dermatoses/surgery , Humans , Male , Nocardia Infections/surgery , Nocardia asteroides/isolation & purificationABSTRACT
Actinomadura madurae mycetoma was diagnosed in two patients by the dermatologic outpatient clinic of the Clementino Fraga Filho University Hospital (UFRJ) and the Antonio Pedro University Hospital (UFF). The first case was a 27-year-old Negro male from the outskirts of Rio de Janeiro, who was injured prior to the onset of the disease in 1988. The affected left foot showed swelling, nodules, sinus tracts, purulent discharge containing grains, and serious bone involvement with lytic lesions. Histological examination showed deeply basophilic stained grains with typical wide-fringed borders. The mycological examination revealed an actinomycete identified as A. madurae by culture. Oral tetracycline for six months did not improve the clinical-radiological picture and the patient was submitted to amputation. The second case was a 70-year-old white male, with previous injury in 1974, which occurred in Pernambuco State. Enlargement of the right foot draining sinuses formation with discharge of pus and grains. In tissue sections the grains were large and surrounded by amorphous eosinophilic clubs radially oriented. There was discrete improvement by tetracycline and sulfonamide. No follow-up.
Subject(s)
Mycetoma/pathology , Nocardia Infections/pathology , Adult , Aged , Foot/microbiology , Foot/pathology , Humans , Male , Mycetoma/microbiology , Nocardia/isolation & purification , Nocardia Infections/microbiologyABSTRACT
18 girls from an orphanage (Orfanato Santo Antônio) in Niterói presented tinea capitis due to Trichophyton tonsurans (15 cases-83.3%) and Microsporum canis (3 cases-26.7%). Comments are made about clinical, mycological and therapeutic aspects of this microepidemic.
Subject(s)
Dermatomycoses/epidemiology , Disease Outbreaks/statistics & numerical data , Microsporum , Tinea Capitis/epidemiology , Brazil/epidemiology , Child , Dermatomycoses/diagnosis , Dermatomycoses/drug therapy , Female , Griseofulvin/administration & dosage , Humans , Microsporum/isolation & purification , Remission Induction , Tinea Capitis/diagnosis , Tinea Capitis/drug therapy , Trichophyton/isolation & purificationABSTRACT
We describe a case of subcutaneous zygomycosis caused by Conidiobolus coronatus of six years' duration. Following treatment failure using potassium iodide, the patient responded with ketoconazole therapy. She remained well three years following therapy. Brazilian cases of subcutaneous infections caused by C coronatus and Basidiobolus ranarum are reviewed.
