Subject(s)
Analgesia/methods , Diabetic Retinopathy/surgery , Laser Coagulation/methods , Music Therapy , Female , Humans , Male , Middle Aged , Music Therapy/methodsABSTRACT
The effect of celebrity diagnosis on public awareness of health conditions has already been well documented. In October 2014, Bono, the lead singer with U2, revealed publicly for the first time that he has glaucoma. This study aimed to analyze the impact of Bono's announcement on public awareness of glaucoma using Google Search trends as an indicator of public interest in the disease. Google Trends was used to examine Google Search activity for the term 'Glaucoma' between 2009 and 2015 in both Ireland and the United Kingdom. Trend analyses were performed using Microsoft Excel Version 14.3.5. Increased Google Search activity for 'Glaucoma' in October 2014 was found in both Ireland and the United Kingdom. A five-fold increase from the mean Google Search activity for this term was found in Ireland and a two-fold increase from the mean Google Search activity for this term was found in the United Kingdom. No such increase in Google Search activity occurred during each country's 2014 Glaucoma Awareness week. Google Trends is useful in medical research as a means of assessing public awareness of, and/or interest in, health related topics. Current approaches to glaucoma related health promotion in both Ireland and the United Kingdom have failed to yield an increase in on-line Google Search activity. While there was an increase in interest in glaucoma it is unclear whether this led to an increase in health seeking behaviour.
Subject(s)
Consumer Health Information/statistics & numerical data , Famous Persons , Glaucoma , Health Behavior , Internet/statistics & numerical data , Music , Awareness , Consumer Health Information/trends , Humans , Internet/trends , Ireland , Male , United KingdomABSTRACT
Golf related ocular injuries are uncommon but frequently result in severe injury necessitating removal of the eye. As golf increases in popularity, it is vital that awareness is raised among both players and spectators regarding the potential hazards. We determined the nature and frequency of golf related eye injury at our unit from 1990 to 2007. Patient age, nature of injury, management and visual outcome were documented. 10 patients (7 adults, 3 children) sustained golf related eye trauma over this time. 7 cases involved injury inflicted by a golf ball and 3 by a golf club. 7 eyes required enucleation or evisceration. Visual acuity in the remaining 3 eyes ranged from 6/6 to less than 6/60. Golf related ocular injuries while uncommon, frequently have devastating consequences. Public awareness must be raised in order to promote greater safety on the golf course.
Subject(s)
Eye Injuries/etiology , Golf/injuries , Adult , Child , Eye Injuries/epidemiology , Female , Humans , Infant , Ireland/epidemiology , Male , Middle Aged , Retrospective Studies , Risk Assessment , Risk FactorsABSTRACT
AIDS: Current clinical trials are listed, with the data drawn from Trials Search, an online database of HIV trials. Study purpose and participant criteria for each trial are described. The trials include HIV drug resistance, antiretroviral therapy, and immunotherapy. Contact information for each trial is provided.^ieng
Subject(s)
Anti-HIV Agents/therapeutic use , Clinical Trials as Topic , HIV Infections/drug therapy , HIV Protease Inhibitors/therapeutic use , Interleukin-2/therapeutic use , AIDS-Related Opportunistic Infections/drug therapy , Adult , Child , Drug Therapy, Combination , HumansABSTRACT
AIDS: Information on various open clinical trails taken from the online database, Trial Search, is provided. The listings include research on HIV drug resistance, antiretroviral therapy, AIDS-related illnesses, pharmacokinetics, and treatment for children. Contact information for Trial Search and each study is provided.^ieng
Subject(s)
Anti-HIV Agents/therapeutic use , HIV Infections/drug therapy , Clinical Trials as Topic , Drug Therapy, Combination , HumansABSTRACT
AIDS: Open clinical trials for HIV/AIDS treatments are described. All listings are taken from the Trials Search database, the American Foundation for AIDS Research web site, and the AIDS Clinical Trials Information Service site. Internet addresses and telephone numbers are included. The criteria and study design for each trial is described, and telephone numbers for further information on enrolling in each trial is included.^ieng
Subject(s)
AIDS-Related Opportunistic Infections/drug therapy , Anti-HIV Agents/therapeutic use , Clinical Trials as Topic , HIV Infections/drug therapy , AIDS-Related Opportunistic Infections/immunology , Adolescent , Adult , Anti-HIV Agents/pharmacokinetics , Child , Child, Preschool , HIV Infections/immunology , Herpes Zoster/immunology , Herpes Zoster/prevention & control , Humans , Immunotherapy , Patient Selection , San Francisco , Viral VaccinesABSTRACT
Gene trapping in murine embryonic stem cells is a proven method for the simultaneous identification and mutation of genes in the mouse. Gene trap vectors are designed to detect insertions within genes through the production of a fusion mRNA transcript, making the identification of the endogenous gene possible by 5' rapid amplification of cDNA ends (RACE). Although the amplification of specific cDNAs can be achieved rapidly, cloning and screening of informative-sized cDNAs has proven to be time consuming. To eliminate the need for cloning, we have developed a method for solid-phase sequencing of 5' RACE products. More than 150 independent gene trap cell lines were analyzed, and sequence information was obtained for every line successfully amplified by RACE. With the vector used in this study, 40% of the cell lines were found to contain properly spliced gene trap events. The remaining lines were either spliced inefficiently or contained deletions of the vector. These results highlight the advantage of sequencing gene trap integrations before further characterization. This work now paves the way for large-scale gene trap screens in mice and should greatly accelerate the functional analysis of the mammalian genome.
Subject(s)
Mutagenesis, Insertional , Sequence Analysis, RNA , Animals , Blotting, Northern , Cell Line , DNA, Complementary , Mice , Molecular Sequence Data , Mutagenesis, Site-Directed , Nucleic Acid Amplification Techniques , Polymerase Chain Reaction , RNA Splicing , Stem CellsABSTRACT
The presence of R-plasmid RP1 increased the adhesion of chemostat-grown iron- and carbon-limited Proteus mirabilis to the surfaces of various medical prostheses and to glass. Similar results were obtained with iron-limited Pseudomonas aeruginosa and anaerobically-grown Escherichia coli. Changes in the surface properties of P. mirabilis indicated that the R-plasmid-mediated increase in negative charge was one of the factors that promoted adhesion.
