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Maintaining the nelfinavir trough concentration above 0.8 mg/L improves virologic response in HIV-1-infected children.
Burger, David M; Bergshoeff, Alina S; De Groot, Ronald; Gibb, Diana; Walker, Sarah; Tréluyer, Jean-Marc; Hoetelmans, Richard M W.
J Pediatr ; 145(3): 403-5, 2004 Sep.
Article in English | MEDLINE | ID: mdl-15343199

ABSTRACT

Differences in virologic response were compared in 32 HIV-infected children with a nelfinavir trough concentration either below (n=7) or above (n=25) 0.8 mg/L. Virologic response at week 48 was observed in 29% of children with subtherapeutic nelfinavir troughs versus 80% in children with therapeutic nelfinavir troughs (P=.02).


Subject(s)
HIV Infections/blood , HIV Protease Inhibitors/pharmacokinetics , Nelfinavir/pharmacokinetics , Child , Child, Preschool , Drug Administration Schedule , Female , HIV Infections/drug therapy , HIV Protease Inhibitors/blood , HIV Protease Inhibitors/therapeutic use , Humans , Male , Nelfinavir/blood , Nelfinavir/therapeutic use
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