Sensitivity analysis of shock distributions in the world economy.

With the ever increasing interconnectedness among countries and industries, globalization has empowered economies and promoted international trade, capital flow and labor mobility, leading to improved products and services. However, the growing interdependence has also propelled an inherent reliance on joint cooperation which has considerably influenced the complexity of global value chains (GVCs). This plays a significant role in policy decisions, raising questions about trade risks that originate from such interdependence. In this paper, we study the impact of network linkage disturbances on the output supply and input demand of countries. We model the network interconnectedness of countries according to the latest 2016 release of the World Input-Output Database (WIOD) that includes data tables for the period 2000-2014 covering 43 countries as well as a model for the Rest of the World (ROW). We assess the shock distributions across the world economy by quantifying the changes in the network linkages using sensitivity analysis. Our contribution is in the definition of a shock tensor with the purpose of evaluating the impact of link sensitivity. The shock tensor is a straightforward yet comprehensive tool that allows us to obtain ample results at various levels of granularity when combining it with aggregation operators. Our study introduces a novel methodology that enables us to acquire input and output link sensitivities for all country pairings when an economic shock initiates or concludes within a country of interest. This innovative approach also facilitates the analysis of evolving trends in these link sensitivities, providing a comprehensive understanding of the dynamics of shock propagation across the global network. Taking advantage of the time-series nature of the WIOD, our results reveal illustrative visualizations and quantative measures that characterize patterns of shock distribution and relationships among countries throughout the period from 2000 to 2014. Our methodology and results not only uncover valuable trends but also establish a structured approach to better understand the aggregate effects of shock distributions. Thus, this study could be helpful for policy makers to assess trade relationships between countries and obtain quantitative insights for making informed decisions as well as explore the overall state of the globalization as a whole.

Review of Natural Language Processing in Pharmacology.

Natural language processing (NLP) is an area of artificial intelligence that applies information technologies to process the human language, understand it to a certain degree, and use it in various applications. This area has rapidly developed in the past few years and now employs modern variants of deep neural networks to extract relevant patterns from large text corpora. The main objective of this work is to survey the recent use of NLP in the field of pharmacology. As our work shows, NLP is a highly relevant information extraction and processing approach for pharmacology. It has been used extensively, from intelligent searches through thousands of medical documents to finding traces of adversarial drug interactions in social media. We split our coverage into five categories to survey modern NLP: methodology, commonly addressed tasks, relevant textual data, knowledge bases, and useful programming libraries. We split each of the five categories into appropriate subcategories, describe their main properties and ideas, and summarize them in a tabular form. The resulting survey presents a comprehensive overview of the area, useful to practitioners and interested observers. SIGNIFICANCE STATEMENT: The main objective of this work is to survey the recent use of NLP in the field of pharmacology in order to provide a comprehensive overview of the current state in the area after the rapid developments that occurred in the past few years. The resulting survey will be useful to practitioners and interested observers in the domain.

Consolidating drug data on a global scale using Linked Data.

BACKGROUND: Drug product data is available on the Web in a distributed fashion. The reasons lie within the regulatory domains, which exist on a national level. As a consequence, the drug data available on the Web are independently curated by national institutions from each country, leaving the data in varying languages, with a varying structure, granularity level and format, on different locations on the Web. Therefore, one of the main challenges in the realm of drug data is the consolidation and integration of large amounts of heterogeneous data into a comprehensive dataspace, for the purpose of developing data-driven applications. In recent years, the adoption of the Linked Data principles has enabled data publishers to provide structured data on the Web and contextually interlink them with other public datasets, effectively de-siloing them. Defining methodological guidelines and specialized tools for generating Linked Data in the drug domain, applicable on a global scale, is a crucial step to achieving the necessary levels of data consolidation and alignment needed for the development of a global dataset of drug product data. This dataset would then enable a myriad of new usage scenarios, which can, for instance, provide insight into the global availability of different drug categories in different parts of the world. RESULTS: We developed a methodology and a set of tools which support the process of generating Linked Data in the drug domain. Using them, we generated the LinkedDrugs dataset by seamlessly transforming, consolidating and publishing high-quality, 5-star Linked Drug Data from twenty-three countries, containing over 248,000 drug products, over 99,000,000 RDF triples and over 278,000 links to generic drugs from the LOD Cloud. Using the linked nature of the dataset, we demonstrate its ability to support advanced usage scenarios in the drug domain. CONCLUSIONS: The process of generating the LinkedDrugs dataset demonstrates the applicability of the methodological guidelines and the supporting tools in transforming drug product data from various, independent and distributed sources, into a comprehensive Linked Drug Data dataset. The presented user-centric and analytical usage scenarios over the dataset show the advantages of having a de-siloed, consolidated and comprehensive dataspace of drug data available via the existing infrastructure of the Web.

Inferring cuisine--drug interactions using the linked data approach.

Food - drug interactions are well studied, however much less is known about cuisine - drug interactions. Non-native cuisines are becoming increasingly more popular as they are available in (almost) all regions in the world. Here we address the problem of how known negative food - drug interactions are spread in different cuisines. We show that different drug categories have different distribution of the negative effects in different parts of the world. The effects certain ingredients have on different drug categories and in different cuisines are also analyzed. This analysis is aimed towards stressing out the importance of cuisine - drug interactions for patients which are being administered drugs with known negative food interactions. A patient being under a treatment with one such drug should be advised not only about the possible negative food - drug interactions, but also about the cuisines that could be avoided from the patient's diet.