1.
J Med Chem
; 44(11): 1654-7, 2001 May 24.
Article
in English
| MEDLINE
| ID: mdl-11356100
Subject(s)
Estradiol Congeners/chemical synthesis , Indoles/chemical synthesis , Animals , Bone Density/drug effects , Cell Line , Estradiol Congeners/chemistry , Estradiol Congeners/metabolism , Estradiol Congeners/pharmacology , Female , Indoles/chemistry , Indoles/metabolism , Indoles/pharmacology , Models, Molecular , Organ Size , Ovariectomy , Radioligand Assay , Rats , Structure-Activity Relationship , Transfection , Uterus/drug effects
2.
Bioorg Med Chem Lett
; 10(2): 147-51, 2000 Jan 17.
Article
in English
| MEDLINE
| ID: mdl-10673099
ABSTRACT
A diastereomerically pure series of 7alpha-thioestratrienes was prepared and evaluated for its affinity for both the human estrogen receptor alpha and the more recently discovered estrogen receptor beta. The functional estrogenic activities of the compounds were measured in a MCF-7 ERE-tk-luciferase assay. The activities and selectivities of the compounds were sensitive to the nature of the thioether side chain.
