ABSTRACT
Three-finger snake neurotoxins are selective antagonists of some nicotinic acetylcholine receptor subtypes and are widely used to study these receptors. The peptide neurotoxin azemiopsin, recently isolated from the venom of Azemipos feae, is a selective blocker of muscle-type nicotinic acetylcholine receptor. In order to reduce their toxicity and increase resistance under physiological conditions, we have encapsulated these toxins into nanomaterials. The study of nanomaterials after interaction with neurotoxins by the methods of transmission electron microscopy and dynamic light scattering revealed an increase in the size of nanoparticles, which indicates the inclusion of neurotoxins in nanomaterials.
Subject(s)
Drug Carriers/chemistry , Nanoparticles/chemistry , Neurotoxins/chemistry , Nicotinic Antagonists/chemistry , Polysaccharides/chemistry , Receptors, Nicotinic/metabolism , Sulfates/chemistry , Capsules , Neurotoxins/toxicity , Nicotinic Antagonists/toxicity , Particle Size , Snake Venoms/chemistryABSTRACT
A multiresolution statistical model, consisting of random fields in wavelet subbands, is proposed for texture, and has produced promising results in texture synthesis experiments. The basic idea here is that a complex random field model, e.g., one that contains long-range and nonlinear spatial correlations, can be constructed from several simpler ones.
