Indoor allergens in settled school dust: a review of findings and significant factors.

The school environment can be an important site of exposure to cat, dog, dust mite, and cockroach allergens, which have been detected in the settled dust of many schools. The sizable body of research that has been published in recent years warrants careful examination. This review article informs clinicians, researchers, and other parties about the potential for exposure in the school environment, factors that affect allergen concentrations, and areas of future research. While average concentrations in schools were usually under risk levels for symptoms or sensitization, many studies reported at least one location where the concentrations exceeded these levels. Maintenance, mechanical, and administrative factors were related to allergen levels in schools. From a clinical perspective, the school environment in industrialized nations has a lower potential for exposure than the home environment, but schools are significant for allergic individuals whose home environment has been addressed to the extent feasible. From a public health perspective, the school environment should be considered as a target for primary and secondary prevention. It can be more practical and amenable to intervene on a single school than the hundreds of homes in a community. Future research should continue to evaluate which interventions are most practical and result in the greatest measurable improvements. In addition, research should further examine the relationship between allergen exposure in schools and health effects, in order to develop an accurate exposure assessment model and risk levels that are specific to the school environment.

Monitor: molecules and profiles.

Monitor provides an insight into the latest developments in drug discovery through brief synopses of recent presentations and publications together with expert commentaries on the latest technologies. There are two sections: Molecules summarizes the chemistry and the pharmacological significance and biological relevance of new molecules reported in the literature and on the conference scene; Profiles offers commentary on promising lines of research, emerging molecular targets, novel technology, advances in synthetic and separation techniques and legislative issues.

Monitor: molecules and profiles.

Monitor provides an insight into the latest developments in drug discovery through brief synopses of recent presentations and publications together with expert commentaries on the latest technologies. There are two sections: Molecules summarizes the chemistry and the pharmacological significance and biological relevance of new molecules reported in the literature and on the conference scene; Profiles offers commentary on promising lines of research, emerging molecular targets, novel technology, advances in synthetic and separation techniques and legislative issues.

Monitor: molecules and profiles.

Monitor provides an insight into the latest developments in drug discovery through brief synopses of recent presentations and publications together with expert commentaries on the latest technologies. There are two sections: Molecules summarizes the chemistry and the pharmacological significance and biological relevance of new molecules reported in the literature and on the conference scene; Profiles offers commentary on promising lines of research, emerging molecular targets, novel technology, advances in synthetic and separation techniques and legislative issues.

Monitor: molecules and profiles.

Monitor provides an insight into the latest developments in drug discovery through brief synopses of recent presentations and publications together with expert commentaries on the latest technologies. There are two sections: Molecules summarizes the chemistry and the pharmacological significance and biological relevance of new molecules reported in the literature and on the conference scene; Profiles offers commentary on promising lines of research, emerging molecular targets, novel technology, advances in synthetic and separation techniques and legislative issues.

Monitor: molecules and profiles.

Monitor provides an insight into the latest developments in drug discovery through brief synopses of recent presentations and publications together with expert commentaries on the latest technologies. There are two sections: Molecules summarizes the chemistry and the pharmacological significance and biological relevance of new molecules reported in the literature and on the conference scene; Profiles offers commentary on promising lines of research, emerging molecular targets, novel technology, advances in synthetic and separation techniques and legislative issues.

Monitor: molecules and profiles.

Monitor provides an insight into the latest developments in drug discovery through brief synopses of recent presentations and publications together with expert commentaries on the latest technologies. There are two sections: Molecules summarizes the chemistry and the pharmacological significance and biological relevance of new molecules reported in the literature and on the conference scene; Profiles offers commentary on promising lines of research, emerging molecular targets, novel technology, advances in synthetic and separation techniques and legislative issues.

Monitor: molecules and profiles.

Monitor provides an insight into the latest developments in drug discovery through brief synopses of recent presentations and publications together with expert commentaries on the latest technologies. There are two sections: Molecules summarizes the chemistry and the pharmacological significance and biological relevance of new molecules reported in the literature and on the conference scene; Profiles offers commentary on promising lines of research, emerging molecular targets, novel technology, advances in synthetic and separation techniques and legislative issues.

Pharmaceutical science and technology today: evolving to reflect the modern industrial life-science environment.

"The barriers between 'silos' in pharmaceutical R&D workflows are slowly eroding and this is driving a wider exchange of information across the various R&D disciplines."

Reflecting on the modern industrial life-science environment.

'The barriers between 'silos' in pharma R&D workflows are slowly eroding and this is driving a wider exchange of information across the various R&D disciplines'

Preparing for change.

'The pharmaceutical industry is seemingly poised on a precipice of intense pressures and challenges'

Preparing for the new millennium.

Since being introduced to the field of drug discovery at Zeneca Pharmaceuticals in 1991, it has become apparent to me that a blizzard of revolutionary novel approaches has swept through the pharmaceutical industry. Now, the discovery process has become completely transformed and the race to develop commercially successful drugs is now taking place in a very different realm. Rapid advances in automation, combinatorial chemistry, high-throughput screening (HTS), genomics, proteomics and bioinformatics appear to be principally responsible for driving such a rapidly evolving discovery process. In these exciting times for pharmaceutical R&D, it is a delight for me to take over the Editor's reins of Drug Discovery Today.