[Incidental renal cancer in young adults: clinical and histopathological findings]. / Cancer renal incidental en pacientes menores de 40 años: hallazgos clinicos e histopatológicos.

OBJECTIVE: to evaluate the clinical and pathological renal cancer (CR) characteristics in our series of tumours, analyzing its impact in the group of age less than 40 years. MATERIAL AND METHODS: We studied 294 patients with CR. The pathologic characteristics were analyzed and DNA ploidy pattern of the surgical pieces were done in 252 patients. The patients were divided in two groups based on age, greater or less to 40 years, well then clinical and pathologic characteristics were compared between. RESULTS: Of all patients, 26 of 294 patients (8,94%) were included in the young age group (less to 40 years). We did not found differences between both groups comparing stage, tumoral volume, treatment realized or DNA ploidy pattern, but in nuclear grade with more aggressive tumours in young people (p=0,0018), without differences in recurrence-free survival or actuarial disease specific survival rate. CONCLUSIONS: The findings in our study indicate that the natural history and outcome of the RC is similar in both older and younger patients. Therefore, in our opinion, the management of CR in young people should be established with independence of the age.

Cáncer renal incidental en pacientes menores de 40 años: hallazgos clínicos e histopatológicos / Inciental renal cancer in young adults: clinical and histopathological findings

Objetivo: Evaluar las características clínicas y patológicas del cáncer renal (CR) en nuestra serie de tumores, analizando su impacto en el grupo de edad de menores de 40 años. Material y método: Se estudiaron 294 pacientes con CR. En 252 se realizó un estudio del ADN tumoral mediante citometría de flujo e histopatológico de las piezas quirúrgicas. Los pacientes fueron divididos en dos grupos en función de la edad, mayores y menores de 40 años. Las características clínicas e histopatológicas fueron comparadas entre ambos grupos. Resultados: De los 294 pacientes, 26 (8,94%) se incluyeron en el grupo de edad menor o igual a 40 años. No hallamos diferencias significativas entre los grupos al comparar estadio, tamaño tumoral o tratamiento realizado, aunque encontramos un mayor número de tumores indiferenciados en los pacientes de menor edad (p=0,018). El análisis del ADN no evidenció diferencias en el porcentaje de aneuplodías al comparar ambos grupos. Tampoco encontramos diferencias al comparar la probabilidad de supervivencia actuarial cáncer específica en función de la edad. Conclusiones: El comportamiento biológico del CR en pacientes menores de 40 años (jóvenes) no parece diferente al del grupo de mayor edad. Por ello pensamos que los esquemas de tratamiento y seguimiento no deben diferir en función de la variable edad

Objective: to evaluate the clinical and pathological renal cancer (CR) characteristics in our series of tumours, analyzing its impact in the group of age less than 40 years. Material and methods: We studied 294 patients with CR. The pathologic characteristics were analyzed and DNA ploidy pattern of the surgical pieces were done in 252 patients. The patients were divided in two groups based on age, greater or less to 40 years, well then clinical and pathologic characteristics were compared between. Results: Of all patients, 26 of 294 patients (8,94%) were included in the young age group (less to 40 years). We did not found differences between both groups comparing stage, tumoral volume, treatment realized or DNA ploidy pattern, but in nuclear grade with more aggressive tumours in young people (p=0,0018), without differences in recurrence-free survival or actuarial disease specific survival rate. Conclusions: The findings in our study indicate that the natural history and outcome of the RC is similar in both older and younger patients. Therefore, in our opinion, the management of CR in young people should be established with independence of the age