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Exp Pathol (Jena) ; 12(6): 301-8, 1976.
Article in English | MEDLINE | ID: mdl-1010009

ABSTRACT

In male Sprague-Dawley rats the relative organ weight and mitotic activity of the adrenal cortex were investigated after intoxication by a single dose of 200 mg/kg b.w. of 2-acetylaminofluorene (AAF) or 20 mg/kg b.w. of allylic alcohol (ALL). 36, 42, 48 and 72 hours after application a significant enhancement of the mitotic rate of the adrenocortical cells was produced by AAF in comparison with that following ALL administration. Interrelations of organ weight and proliferative activity could not be found.


Subject(s)
2-Acetylaminofluorene/poisoning , Adrenal Cortex/drug effects , Adrenal Glands/drug effects , Fluorenes/poisoning , Propanols , 1-Propanol/poisoning , Adrenal Cortex/physiology , Allyl Compounds/poisoning , Organ Size/drug effects
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