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Boll Soc Ital Biol Sper ; 54(22): 2319-25, 1978 Nov 30.
Article in Italian | MEDLINE | ID: mdl-224892

ABSTRACT

Male and female rats were treated with estradiol benzoate in the 5 degrees day of life. The avoidance conditioning, tested after 65 days, was significatively impaired in males treated with estradiol, a significative retardation was observed in females treated, but no significant end-difference versus no-treated females. It is supposed that a hormone induced synaptic shaft/spines ratio in preoptic area may be involved in avoidance conditioning.


Subject(s)
Avoidance Learning/drug effects , Estradiol/pharmacology , Amygdala/drug effects , Animals , Female , Gonadotropins/metabolism , Male , Preoptic Area/drug effects , Rats , Receptors, Neurotransmitter/drug effects , Sex Factors
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