[Non-specific fermentemia as a possible cause of postoperative disorders of motor function of the small intestine]. / Nespetsificheskaia fermentemiia kak vozmozhnaia prichina posleoperatsionnykh narushenii motornoi funktsii tonkoi kishki.

The authors studied duodenal myoelectric activity and the activity of trypsin, alpha 1-antitrypsin, alpha 2-macroglobulin, alpha-amylase, and kallikrein after 15-minute occlusion of the hepatic portal vein. The correlation was found between the activity of alpha 1-antitrypsin and the phases of the myoelectrical complex. It is concluded that the discharge of pancreatic proteases during an operative trauma may underlie the pathogenesis of postoperative inhibition of intestinal peristalsis.

[Effects of opioid neuropeptides on the prostaglandin system and lipid peroxidation processes in the myocardium during stress-induced damage]. / Vliianie opioidnykh neiropeptidov na sistemu prostaglandinov i protsessy perekisnogo okisleniia lipidov v miokarde pri ego stressornom povrezhdenii.

The stress was subsequenced by lowering of Thromboxane A2 level and activation of peroxidation of lipids without any changes of prostacyclin content in myocardium. It was found that the pre-increase of the opioid peptides in blood plasma led to the absence of prostacyclin and thromboxane dynamic and myocardial lipids peroxidation inhibition during the subsequent stress.

[The effect of obzidan, finoptin and Ca2+ on the cAMP level during contraction-relaxation of isolated heart of guinea pigs activated with isadrin]. / Deistvie obzidana, finoptina i Ca2+ na soderzhanie cAMP v protsesse sokrashcheniia-rasslableniia izolirovannogo serdtsa morskoi svinki, aktivirovannogo izadrinom.

The beta-adrenoceptor blockade, slow inward calcium current blockade and calcium concentration decrease in perfusion solution were studied for their effect on cAMP oscillations during cardiac cycle in the isadrin-activated isolated heart of guinea pig. Isadrin activation (3 X 10(-8) M) of beta-adrenoceptors caused an increase of the cAMP concentration by 50% during the contraction. All the actions decreased an average level of cyclonucleotide in the myocardium as compared with isadrin and what is more, obsidan (10(-6) M) removed the cAMP oscillations almost completely, the hypocalcium solution (0.15 mM Ca2+) decreased their amplitude and duration, finoptin (3 X 10(-8) M) qualitatively changed the oscillation profile. The results obtained make it possible to suggest, that a change in the concentration of ionized calcium in myoplasma is one of the reasons inducing changes in the cAMP during the cardiac cycle.

[The role of the renin-angiotensin-aldosterone system and vasopressin in the development of heart failure during continuous electric stimulation of the heart]. / Rol' sistemy renin-angiotenzin-al'dosteron i vazopressina v razvitii serdechnoi nedostatochnosti pri postoiannoi élektrostimuliatsii serdtsa.

The status of the renin-angiotensin-aldosterone system and the time course of vasopressin levels were studied in patients with an implanted cardiostimulator. Activation of plasma renin due to renal hypoperfusion in an inadequate stimulation was demonstrated to be followed by a rise in aldosterone and vasopressin concentrations and by an increase in blood volumes. Activation of angiotensin II and vasopressin resulted in higher peripheral resistance. Altered humoral regulation of the circulation retained 6-12 months after cardiostimulator implantation, by maintaining myocardial overload with volume and resistance.