1.
J Pharm Sci
; 64(12): 1943-9, 1975 Dec.
Article
in English
| MEDLINE
| ID: mdl-1107515
ABSTRACT
The syntheses of seven anthracene amino alcohols with one, two, or three additional substituents are described. These compounds include three 1-aminoethanols, two 9-aminoethanols, and two 9-aminopropanols, prepared from substituted anthraquinones or from 10-chloro-9-anthraldehydes. The antimalarial activity of these compounds, as well as tentative structure-activity relationships, is discussed in the light of previously published work.
Subject(s)
Amino Alcohols , Anthracenes , Antimalarials , Amino Alcohols/chemical synthesis , Amino Alcohols/therapeutic use , Animals , Anthracenes/chemical synthesis , Anthracenes/therapeutic use , Antimalarials/chemical synthesis , Antimalarials/therapeutic use , Malaria/drug therapy , Mice , Plasmodium berghei , Structure-Activity Relationship
2.
J Med Chem
; 15(8): 861-3, 1972 Aug.
Article
in English
| MEDLINE
| ID: mdl-5044308
Subject(s)
Aldehydes/chemical synthesis , Amino Alcohols/chemical synthesis , Anthracenes/chemical synthesis , Antimalarials/chemical synthesis , Aldehydes/therapeutic use , Amino Alcohols/therapeutic use , Animals , Anthracenes/therapeutic use , Antimalarials/therapeutic use , Chickens , Malaria/drug therapy , Mice , Structure-Activity Relationship
3.
J Med Chem
; 14(2): 90-4, 1971 Feb.
Article
in English
| MEDLINE
| ID: mdl-5544415