Ion imaging in a high-gradient magnetic guide.

We study a photoionization method to detect and image a narrow beam of cold atoms traveling along a high-gradient two-wire magnetic guide that is continuously on. Ions are accelerated in a compact acceleration region, directed through a drift region several centimeters in length, and detected using a position-sensitive ion detector. The potentials of several electrodes can be varied to adjust the imaging properties. Using ion trajectory simulations as well as experiments, we study the passage of the ions through the detection system, the magnification of the detection system, and the time-of-flight characteristics.

Strategies for processing unbounded dependencies: lexical information and verb-argument assignment.

This article describes 2 experiments about verb-argument relations in sentence processing in which there is no ambiguity involving the subcategorization of the verb but in which the role that the argument serves is initially unclear. Specifically, a self-paced reading experiment and an eye-tracking experiment investigated the way in which readers form unbounded dependencies when the verb is looking for both a direct object and a clause and when the filler either could be the direct object or could form part of the clause. The results suggested that readers treated the filler as the verb's direct object and probably also considered the clausal analysis at the same time. The results are interpreted with respect to current accounts of parsing.

Reading time evidence for enriched composition.

Verbs like 'begin' and 'enjoy' appear to semantically select a complement that expresses an activity or an event (Jackendoff, R. (1997). The architecture of the language faculty. Cambridge, MA: MIT Press; Pustejovsky, J. Cognition 41 (1991) 47; Pustejovsky, J. (1995). The generative lexicon. Cambridge, MA: MIT Press). When these verbs occur with a complement that does not directly denote either an activity or an event (e.g. '... began the book' or '... enjoyed the book'), the complement must be type-shifted from an object to an activity to conform to the verb's semantic restrictions. We report an experiment in which self-paced reading times were found to be longer for complements that required type-shifting than for complements that directly matched the semantic restrictions of the matrix verb. This finding is argued to provide on-line evidence for a type of enriched lexical processing posited in recent lexical semantic research.

Effects of sentence constraint on priming in natural language comprehension.

In 4 cross-modal naming experiments, researchers investigated the role of sentence constraint in natural language comprehension. On the sentence constraint account, incoming linguistic material activates semantic features that in turn pre-activate likely upcoming words. The 1st and 2nd experiments investigated whether stimulus offset asynchrony played a critical role in previous studies supporting the sentence constraint account. The 3rd and 4th experiments examined further predictions of the sentence constraint account, in particular whether pre-activated words would compete for activation. In Experiment 3, the researchers manipulated whether an expected target word had a close competitor and found that response to the expected word was facilitated regardless of the proximity of a competitor. The 4th experiment established that close competitors were primed by the sentence frames and should have been available to compete with expected target words. Thus, word-level representations did not compete for activation.

Platelet-derived growth factor-AA and -alpha receptor expression suggests an autocrine and/or paracrine loop in osteosarcoma.

Platelet-derived growth factor (PDGF) is a major mitogen and chemotactic factor for mesenchymal cells such as fibroblasts, smooth muscle cells, and osteoblasts. PDGF exists as disulfide-linked homo- or heterodimers composed of two polypeptide chains encoded by distinct genes, designated PDGF-A and PDGF-B. Upon binding to its tyrosine kinase receptor PDGF-alpha, especially PDGF-AA stimulates the proliferation of osteoblastic cells and may exert autocrine and paracrine effects in regulating bone-forming processes. The purpose of this immunohistochemical study was to determine the expression of PDGF-AA and PDGF-alpha receptor in benign and malignant neoplastic bone lesions. Polyclonal antibodies to PDGF-AA and PDGF-alpha receptor were used on paraffin sections of 23 osteosarcomas and 17 osteoblastomas. Immunostaining was assessed quantitatively by evaluating the percentage of reactive tumor cells. In osteosarcomas, the mean expression of PDGF-AA and PDGF-alpha receptor was 33.97% (range, 2 to 80%; SD, 24.26%) and 27.13% (range, 3.2 to 72%; SD, 18.38%), respectively. Osteoblastomas showed significantly lower expression of PDGF-AA than osteosarcomas (mean, 15.71%; range, 5 to 34%; SD, 9.43%; P = .019). Although the mean expression of PDGF-alpha receptor in osteoblastomas was much lower than in osteosarcomas (mean, 17.55%; range, 3.6 to 26.8%; SD, 6.47%), the difference was not significant (P = .122). For osteosarcomas, Spearman correlation coefficient (two-tailed) revealed a significant correlation between the expression of PDGF-AA and PDGF-alpha receptor (r = .688), which was not the case for osteoblastomas (r = .267). These data suggest that in contrast to osteoblastoma, the growth of osteosarcoma may be supported by the coordinate expression of the potent mitogenic growth factor and its receptor that exert their functions by autocrine and paracrine mechanisms.

Priming in sentence processing: intralexical spreading activation, schemas, and situation models.

A series of eye-tracking experiments investigated priming in natural language understanding. Intralexical spreading activation accounts of priming predict that the response to a target word will be speeded (i.e., primed) when strong associates appear prior to the target. Schema-based priming accounts predict that priming will occur when the target word is a component of an activated schema or script. Situation model accounts predict that priming will occur when a target word can be integrated easily into an evolving discourse representation. In separate experiments, we measured the effect of associated words, synonyms, and identity primes on processing times for subsequently encountered target words. Our designs crossed prime type (e.g., synonyms vs. unassociated words) with semantic plausibility (i.e., the target word was a plausible vs. an implausible continuation of the sentence). The results showed that identity primes, but not associates or synonyms, primed target words in early measures of processing like first fixation and gaze duration. Plausibility effects tended to emerge in later measures of processing (e.g., on total reading time), although some evidence was obtained for early effects of semantic plausibility. We propose that priming in naturalistic conditions is not caused by intralexical spreading activation or access to precompiled schemas.

Predicting forage indigestible NDF from lignin concentration.

We used chemical composition and in vitro digestibility data from temperate and tropical forages to develop relationships between indices of lignification and forage indigestible NDF. Neutral detergent fiber indigestibility increased nonlinearly as the lignin concentration of the NDF increased. Differences in estimated indigestible NDF using equations developed for a specific forage class (C3 and C4 grasses and legumes) were small and are probably not biologically significant when compared to those estimated from a common equation. Selected equations were compared with the Cornell Net Carbohydrate and Protein System (CNCPS) for the prediction of ADG. The linear equation (2.4 times NDF lignin content) used by the CNCPS and the Beef NRC had some of the largest errors due to mean bias. A log-log model [4.37 x (lignin/NDF)(.84)] provided the best combination of low total prediction error, low mean bias, and minimal error due to regression bias when permanganate lignin was used. A similar equation based on sulfuric acid lignin [6.17 x (lignin/NDF)(.77)] also met the above criteria. These equations then were evaluated with the CNCPS model against animal growth data from diets ranging in forage quality. Regardless of the equation used for predicting unavailable fiber, the CNCPS underpredicted daily gain, with mean biases ranging from -.10 to -.22 kg/d. Regression bias ranged from .13 to .14 kg/d and the coefficients differed from unity (P = .0001). The new equations gave numerically lower energy allowable ADG by steers compared to the linear equation currently used by the CNCPS model. The estimates were lower due to a higher predicted indigestible NDF, which resulted in a lower estimated forage energy value.

Children's literature for the primary inclusive classroom: increasing understanding of children with hearing impairments.

As a result of recent federal legislation and positive research findings of educators, children with disabilities, including hearing impairment, are being included in general education classrooms. This development has many implications at the state, district, and classroom levels. While helping the child with disabilities assimilate into the general education classroom may appear to be the teacher's primary challenge, increasing awareness and understanding among those students without disabilities is a growing concern of educators. The use of children's literature featuring children with disabilities is one way to promote this understanding. This article includes an annotated bibliography of children's literature featuring children with hearing impairment, along with related classroom activities to enhance experiences with the books.

Case-marking in the parsing of complement sentences: evidence from eye movements.

An eye-tracking experiment investigated the role of case-marking in parsing. We manipulated the case of pronouns in reduced complement sentences like I recognized you and your family would be unhappy here and I recognized she and her family would be unhappy here, in which the nominative pronoun she immediately disambiguates the sentences, in contrast to the ambiguous you. The nominative pronoun she disambiguates the sentence because I recognised she is ungrammatical, and thus she and her family must be the subject of an embedded sentence and not the NP-object of the preceding verb. Subjects took longer to read she and her family than you and your family during initial processing. The pattern reversed at the disambiguating phrase would be. Unambiguous control sentences containing the complementizer that did not produce case-marking effects. These results demonstrate very rapid effects of case-marking on parsing. Either case information is used immediately, or it is employed after an extremely short delay. We discuss implications for current theories of parsing.

Imaging of unerupted and displaced teeth by cross-sectional CT scans.

Thirty-six impacted and displaced teeth in 29 patients were examined radiographically by using orthopantomography (OPG) and computed tomography (CT). CT scans were obtained by using both a conventional program and a dental CT software program. The radiographic images obtained were compared for visualization of the internal position, inclination of unerupted teeth, and diagnosis of contact and doubtful or clearly visible resorption of adjacent roots. Both CT methods were superior to OPG. As far as the internal position and inclination of the impacted teeth, direct contact, and clearly visible resorption are concerned, the conventional CT program yielded the same information as the dental CT program. However, the exact proportional cross-sectional views obtained by dental CT yielded significantly (P < 0.01) better information about doubtful root resorption in adjacent teeth than did conventional CT.

Influence of roughage and grain processing in high-concentrate diets on the performance of long-fed Holstein steers.

The effects of roughage source and timing of inclusion in high-concentrate diets on feedlot performance were evaluated in each of 2 yr with 144 and 120 long-fed Holstein steers, respectively. Roughage, when included in the diet, was delivered in a built-in-roughage (BIR) pellet supplying 15 and 6% roughage (percentage of DM) or hay crop silage (HCS) supplying 7 and 10% roughage (percentage of DM) for the growing and finishing periods, respectively. The six dietary treatments (two pens each) investigated were continuous whole corn and pelleted supplement (no added roughage; WSC-PEL); BIR with cracked corn either in the growing (BIR-G) or finishing (BIR-F) period with whole corn being fed with pelleted supplement when BIR was not part of the diet; BIR and cracked corn fed continuously (BIR-CONT); and two HCS treatments in which the corn was fed either whole (HCS-WSC) or cracked (HCS-CSC) for the entire feeding period. Replicates were slaughtered 4 and 3 wk apart for yr 1 and 2, respectively. Pooled daily gains (yr 1 and 2) for the entire trial (1.39 to 1.45 kg/d) were not different (P > .05). Daily DM and concentrate intakes were lower (P < .001) and gain efficiency was higher (P < .001) for the WSC-PEL than for the other treatments. Carcass characteristics were similar among treatments except for an improved yield grade (P < .02) for the HCS treatments over the BIR treatments. The WSC-PEL treatment was the most profitable (+/steer) and the BIR-CONT diet was the least profitable. The HCS treatments were the most profitable of the roughage treatments. A newly proposed intake prediction equation for feedlot cattle performed similarly to the 1984 NRC equation with long-fed Holstein steer calves.

Breast and cervical cancer screening of poor, elderly, black women: clinical results and implications. Harlem Study Team.

Our objective is to describe the clinical findings from a nurse-practitioner-based breast and cervical cancer screening program for poor, elderly, black women. We designed a cross-sectional descriptive study set at an urban public hospital medical clinic. All women 65 years of age and older were eligible to be screened. We measured these main outcomes: rates of participation, abnormal tests, and neoplasia. Women were offered screening during a routine visit. Of 689 women, 491 (71%) participated. Mammography was completed by 66% of women; one had stage 1 cancer, and 76% were negative. Among the women (24%) with abnormal mammograms, the overwhelming majority were diagnosed with benign lesions. For ten of 450 women completing Papanicolaou (Pap) smears, results were suspicious or positive for malignancy, for a prevalence rate of 22.2/1,000 (95% confidence interval [CI] = 8.6/1,000 to 35.8/1,000). Three were subsequently designated falsely positive; five had confirmed cervical neoplasia; and two had other reproductive malignancies. Two women with negative smears also had neoplasia: one with vulvar cancer and one with human papilloma virus (HPV) infection and cervical neoplasia, for a total of six cervical neoplasias. Interestingly, one-fifth of women with a hysterectomy had an intact cervix, including one with cervical neoplasia. Nearly one-third of women with abnormal Paps or mammograms failed to complete follow-up. Success of screening programs for the elderly will depend on the risk group targeted, careful examination, degree of sensitivity and specificity of the tests, and acceptability of follow-up diagnosis and treatment.

A nurse practitioner intervention to increase breast and cervical cancer screening for poor, elderly black women. The Harlem Study Team.

OBJECTIVE: To compare nurse practitioner (NP) and physician rates of breast and cervical cancer screening among poor, elderly black women. DESIGN: A quasi-experimental design was used to compare pre- and postintervention annual screening rates. Rates were determined by medical record audits. SETTING: Two urban public hospital primary care clinics served as the study sites. PATIENTS: All women aged 65 years or more were eligible to participate. INTERVENTIONS: Women were offered screening by a NP during a routine visit in the intervention site; a physician reminder system was used in the control site. MAIN RESULTS: Baseline annual screening rates were comparable in the two study sites. At the end of the study period, rates were significantly higher in the NP site, compared with the control. In the NP clinic, the annual rate of Pap tests increased to 56.9% from the baseline of 17.8%, and mammographies increased to 40% from 18.3%. In comparison, rates remained low in the control site, increasing only to 18.2% of women receiving Pap tests from a baseline of 11.8%, and remaining at 18% for mammography. CONCLUSIONS: Use of a NP to deliver same-day screening is an effective strategy to target poor, elderly black women for breast and cervical cancer screening. However, even with the substantial increases in rates obtained with the NP intervention, screening in this vulnerable population remains below nationally targeted levels.

Targeting breast and cervical cancer screening to elderly poor black women: who will participate? The Harlem Study Team.

BACKGROUND: Factors associated with participation in breast and cervix cancer screening among elderly black women of low socioeconomic status were determined. METHODS: Data from a baseline cross-sectional random survey were used together with data on whether screening was subsequently completed or refused. The subjects were a random sample of women attending an urban public hospital primary care clinic for routine medical care with a birth year of 1924 or earlier. RESULTS: Among the 271 women in the study group, 70% completed screening. Stated intent was the strongest predictor of participation; women who intended to have both mammography and Pap testing were 2.7 times more likely to participate than those who intended to have neither test (95% confidence interval 1.4, 4.9; P < 0.01), controlling for age, insurance status, and level of chronic illness. Women who had more than three chronic illnesses were twice as likely to participate than those with three or fewer illnesses (95% confidence interval 1.1, 3.4 P < 0.02), controlling for the remaining variables. Other variables, including age, history of a recent screening examination, attitudes, or knowledge, were not related to participation. Stated intent was the only variable that predicted compliance with both mammography and Pap smear completion in separate regression models for the individual tests. CONCLUSION: A high proportion of elderly, socioeconomically disadvantaged black women will participate in cancer screening when it is offered in a primary care setting. Further research on behavioral intentions should be conducted to refine interventions designed to enhance the use of early cancer detection among vulnerable population groups.

Sonography of nonneoplastic disorders of the salivary glands.

We examined 637 patients with salivary gland disorders by real-time sonography. In 270 patients, the possibility of neoplasia of the salivary glands could not be excluded by ultrasound. In the remaining 367 patients, the following disorders were diagnosed sonographically: acute inflammation (72 patients), Sjögren's syndrome or chronic inflammation (81 patients), abscess (9 patients), sialolithiasis (192 patients), and cysts (13 patients). The present study discusses the ultrasound appearances of a variety of diseases and the indications and limits of sonography in the evaluation of salivary gland pathology.

Mammography and Papanicolaou smear use by elderly poor black women. The Harlem Study Team.

OBJECTIVE: To describe factors related to the use of mammography and Papanicolaou smears in low-income women aged 65 or more years to guide development of future interventions. DESIGN: A cross-sectional survey. SETTING AND PATIENTS: Elderly Black women attending a public hospital medical clinic. MEASUREMENTS: Information obtained in a face-to-face interview of a random sample of patients. RESULTS: Four-hundred and forty-five women (94%) consented to be interviewed; 74% reported a mammogram, and 85% reported a Papanicolaou smear in the past, although these early-detection tests were not obtained with any regularity after age 65. Concordance between self-reported screening use and blind chart review was more than 90%. The major reasons for non-use of both screening tests were that a physician hadn't recommended them or that the women didn't know they needed them. Levels of knowledge about breast and cervix cancer were low; 68% believed bumping or bruising the breast caused cancer, and only 25% knew that cancer risk increased with advancing age. In logistic regression models, health status, provider type, perceived benefit, life satisfaction, and knowledge of test intervals were each significantly associated with mammogram use. Age, health status, education, perceived susceptibility and benefit, life satisfaction, and knowledge of test intervals were independently related to Pap use (P < .05). CONCLUSION: This study illustrates that elderly, poor, minority women who are regular health-care users do use mammography and Pap smear screening services. Incorporating screening into routine primary care and physician and patient education could enhance the use of early cancer detection procedures in this age group.

Is human papillomavirus associated with cervical neoplasia in the elderly?

There have been no studies in the United States of human papillomavirus (HPV) in elderly women. This paper presents cross-sectional data on HPV and cervical neoplasia among 232 women age 65 or more. HPV deoxyribonucleic acid (DNA) testing was performed using a modified dot-blot hybridization technique. The prevalence of HPV DNA positivity was 3.5% (95% confidence interval (CI) 0.9%, 6.0%). There were six cases of histologic cervical neoplasia. The crude odds ratio for cervical neoplasia among HPV DNA positives was 18.3 (95% CI 2.8, 120.3). The adjusted odds, controlling for age, prior screening history, current sexual activity, and past contraception use, were 12.2 (95% CI 1.2, 122.9). Ever having had a Papanicolaou smear was protective, and there was a trend for the odds of having neoplasia to increase with age. Additional studies with larger samples of elderly women are needed. If confirmed, the results suggest that, independent of past screening, HPV may increase the risk of having cervical neoplasia for elderly women.

Sonographic measurement versus mapping for determination of residual ridge width.

To achieve long-term success of dental implants, evaluation of the dimensions of the resorbing alveolar process must be accurate because an implant should be surrounded by at least 1 mm of bone. Estimating the thickness of bone is more difficult because the mucosal contour can mask the actual dimension of the residual ridge. With ultrasound, it is possible to analyze and visualize the diameter of maxillary or mandibular residual ridges. Data obtained from ultrasound measurement of residual ridges were compared with the data from ridge mapping with the Wilson bone caliper and the Spoerlein caliper. The ultrasound measurement produced nearly the same data at all measurement points as ridge mapping. Ultrasound also provides exact information about the location of the mental foramen and the maxillary sinus. By using all three methods the initial stage of implant treatment can be planned.

Magnetic resonance in lesions of the parotid gland.

In a prospective study the relevance of magnetic resonance (MR) for the diagnoses of tumors of the parotid gland has been evaluated. Due to the excellent soft tissue contrast and also the possibility of imaging in various planes and sections and to the high resolution achieved by surface coils, it was possible to visualize the lesions and the surrounding anatomy in great detail. MR combines the advantages of ultrasound and computed tomography and is indicated if a tumor cannot be defined sharply by using ultrasound or CT.