Subject(s)
3-Hydroxysteroid Dehydrogenases/genetics , Ichthyosis/genetics , Limb Deformities, Congenital/genetics , Mutation , Nevus/genetics , Adolescent , Amino Acid Sequence , DNA Mutational Analysis , Female , Humans , Ichthyosis/diagnosis , Limb Deformities, Congenital/diagnosis , Molecular Sequence Data , Mutation, Missense , Nevus/diagnosis , Point Mutation , Polymorphism, Single Nucleotide , Sequence Alignment , Sequence DeletionSubject(s)
Central Nervous System Neoplasms/pathology , Glioma/pathology , Nose , Female , Humans , Infant, NewbornABSTRACT
Benign dermatoses in newborns must be distinguished from more serious disorders with cutaneous manifestations. Erythema toxicum neonatorum, transient neonatal pustular melanosis, sucking blister, miliaria and mongolian spots are among the many benign skin conditions that can occur in newborns. Recognition of these dermatoses allows the physician to proceed appropriately, reassure the parents and initiate further evaluation or treatment as necessary. To avoid adverse sequelae, special attention must be given to more persistent conditions and those with the potential for complications or malignant transformation. Consultation with a pediatric dermatologist, a plastic surgeon or a neurosurgeon may be necessary.
Subject(s)
Skin Diseases , Diagnosis, Differential , Humans , Infant, Newborn , Skin Diseases/diagnosis , Skin Diseases/therapyABSTRACT
Cutaneous lesions of anaplastic large cell (CD30+) lymphoma (ALCL) typically present as solitary or multiple ulcerated nodules. This tumor is histologically characterized by a diffuse dermal and sometimes subcutaneous infiltrate composed of bizarre, pleomorphic, neoplastic cells that may be occasionally multinucleated. We report a case of extranodal spread of ALCL to the skin in a 2 1/2-year-old boy presenting as a widespread papular eruption that on biopsy showed lymphoma restricted to the perivascular and periadnexal dermis.
