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dMi-2, a hunchback-interacting protein that functions in polycomb repression.

Kehle, J; Beuchle, D; Treuheit, S; Christen, B; Kennison, J A; Bienz, M; Müller, J.

Science ; 282(5395): 1897-900, 1998 Dec 04.

Article in English | MEDLINE | ID: mdl-9836641

ABSTRACT

Early in Drosophila embryogenesis, gap gene products directly repress transcription of homeotic (HOX) genes and thereby delimit HOX expression domains. Subsequently, Polycomb-group proteins maintain this repression. Currently, there is no known molecular link between gap and Polycomb-group proteins. Here, dMi-2 is identified as a protein that binds to a domain in the gap protein Hunchback that is specifically required for the repression of HOX genes. Genetic analyses show that dMi-2 participates in both Hunchback and Polycomb repression in vivo. Hence, recruitment of dMi-2 may serve as a link between repression of HOX genes by Hunchback and Polycomb proteins.

Subject(s)

Adenosine Triphosphatases , Autoantigens/genetics , Autoantigens/metabolism , Carrier Proteins/genetics , Carrier Proteins/metabolism , DNA-Binding Proteins/metabolism , Drosophila Proteins , Gene Expression Regulation, Developmental , Genes, Homeobox , Insect Proteins/metabolism , Transcription Factors/metabolism , Animals , Autoantigens/chemistry , Carrier Proteins/chemistry , DNA-Binding Proteins/genetics , Drosophila/embryology , Drosophila/genetics , Embryo, Nonmammalian/metabolism , Gene Dosage , Genes, Insect , Genetic Complementation Test , Germ Cells/metabolism , Heterozygote , Homeodomain Proteins/genetics , In Situ Hybridization , Insect Proteins/genetics , Mutation , Polycomb Repressive Complex 1 , Recombinant Fusion Proteins

ABSTRACT

Subject(s)

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