ABSTRACT
HLA typing was performed on 18 patients suffering from sarcoidosis and 30 patients suffering from diffuse interstitial pulmonary fibrosis. One hundred normal healthy people ethnically matched served as the controls. On statistical analysis, the corrected 'p' value of all the HLA antigens for both the patient groups was non significant. The results therefore suggest that there is no particular HLA antigen associated with sarcoidosis and diffuse interstitial pulmonary fibrosis.
Subject(s)
HLA Antigens/analysis , Lung Diseases/immunology , Pulmonary Fibrosis/immunology , Sarcoidosis/immunology , Case-Control Studies , Ethnicity , HLA-A Antigens/analysis , HLA-B Antigens/analysis , HLA-B39 Antigen , HLA-C Antigens/analysis , HLA-DR Antigens/analysis , HumansABSTRACT
Twenty-five resident doctors were given 1 ml (20 micrograms) of recombinant hepatitis B vaccine intramuscularly in the deltoid region at 0, 1 and 6 months. Seroconversion rates at 1, 2, 3, 7 and 8 months were 8%, 48%, 64%, 96% and 100% respectively. Acceptability of the vaccine was 100%. The recombinant hepatitis B vaccine is safe and efficacious, with seroconversion rates comparable to the plasma derived vaccine, and has negligible side effects.
Subject(s)
Hepatitis B/prevention & control , Occupational Diseases/prevention & control , Physicians , Viral Hepatitis Vaccines , Adult , Female , Hepatitis B Vaccines , Humans , Male , Recombinant Proteins , Time Factors , VaccinationSubject(s)
HLA Antigens , HLA-B Antigens , Multiple Sclerosis/immunology , Ethnicity , Humans , IndiaABSTRACT
The infrequency of multiple sclerosis in India may have genetic implications. We found (a) the HLA-A3 and HLA-B7 haplotypes amongst Indians to be lower than those reported in Caucasians, (b) no excess of HLA-A3 and HLA-B7 amongst our 27 multiple sclerosis patients compared to 330 controls; instead it was the reverse, (c) HLA-B12 as high as 74% in the "clinically definite" cases, against only 9% in controls, (d) a significant relative risk of MS amongst Indians with HLA-B12 haplotype. Attention is drawn to th higher incidence of MS amongst the small Parsee community and the high association of HLA-B12 in these patients.
Subject(s)
HLA Antigens/analysis , Multiple Sclerosis/immunology , White People , Humans , India , Multiple Sclerosis/geneticsABSTRACT
In Indian patients with Multiple Sclerosis it was observed, upon testing for serum determinable histocompatibility antigens, that HLA-B12 antigen was present in excess (77.7%), in comparison with normal controls (13.8%). In fact, in the sub-group of 'clinically definite' patients, the B12 antigen excess was remarkable (84%). These preliminary findings seem to point to a different immunogenetic profile of Indian MS patients in comparison with Western and Japanese series. Relevant published information relating to the HLA-B12 alleles in disease processes is discussed in order to provide a basis for further work.
