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1.
Eur J Clin Microbiol Infect Dis ; 36(2): 219-225, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27714593

ABSTRACT

Acinetobacter baumannii is an important cause of multidrug-resistant hospital acquired infections in the world. Here, we investigate the presence of NDM-1 and other carbapenemases among carbapenem-resistant A. baumannii isolated between August 2010 and December 2014 from three large hospitals in Hanoi, Vietnam. We identified 23/582 isolates (4 %) (11 from hospital A, five from hospital B, and seven from hospital C) that were NDM-1 positive, and among them 18 carried additional carbapenemase genes, including seven isolates carrying NDM-1, IMP-1, and OXA-58 with high MICs for carbapenems. Genotyping indicated that NDM-1 carrying A. baumannii have expanded clonally in these hospitals. Five new STs (ST1135, ST1136, ST1137, ST1138, and ST1139) were identified. One isolate carried NDM-1 on a plasmid belonging to the N-repA replicon type; no NDM-1-positive plasmids were identified in the other isolates. We have shown the extent of the carbapenem resistance and the local clonal spread of A. baumannii carrying NDM-1 in these hospitals; coexistence of NDM-1 and IMP-1 is reported for the first time from Vietnam here, and this will further seriously limit future therapeutic options.


Subject(s)
Acinetobacter Infections/microbiology , Acinetobacter baumannii/enzymology , Acinetobacter calcoaceticus/enzymology , Bacterial Proteins/metabolism , beta-Lactamases/metabolism , Acinetobacter Infections/epidemiology , Acinetobacter baumannii/classification , Acinetobacter baumannii/genetics , Acinetobacter baumannii/isolation & purification , Acinetobacter calcoaceticus/classification , Acinetobacter calcoaceticus/genetics , Acinetobacter calcoaceticus/isolation & purification , Adolescent , Adult , Aged , Carbapenems/pharmacology , Child , Child, Preschool , Female , Genotype , Hospitals , Humans , Infant , Male , Microbial Sensitivity Tests , Middle Aged , Molecular Typing , Plasmids/analysis , Prospective Studies , Vietnam/epidemiology , Young Adult , beta-Lactam Resistance
2.
Eur J Clin Microbiol Infect Dis ; 34(6): 1247-54, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25732142

ABSTRACT

This study sought to monitor the presence of carbapenem-resistant Enterobacteriaceae (CRE) and the proportion New Delhi metallo-beta-lactamase 1 (NDM-1)-producing bacteria between August 2010 and December 2012 in a surgical hospital in Vietnam. We identified 47 CRE strains from a total of 4,096 Enterobacteriaceae isolates (1.1 %) that were NDM-1-positive from 45 patients admitted to 11 different departments, with the majority being from the urology department. The NDM-1 gene was found in seven different species. Genotyping revealed limited clonality of NDM-1-positive isolates. Most of the isolates carried the NDM-1 gene on a plasmid and 17.8 % (8/45) of those were readily transferable. We found five patients at admission and one patient at discharge with NDM-1-positive bacteria in their stool. From 200 screening environmental hospital samples, five were confirmed to be NDM-1-positive and included Acinetobacter species (n = 3) and Enterobacter aerogenes (n = 2). The results reveal that NDM-1-producing Enterobacteriaceae are commonly isolated in patients admitted to a Vietnamese surgical hospital and are also detected in the hospital environment.


Subject(s)
Enterobacteriaceae Infections/epidemiology , Enterobacteriaceae Infections/microbiology , Enterobacteriaceae/enzymology , Enterobacteriaceae/isolation & purification , beta-Lactamases/metabolism , Adolescent , Adult , Aged , Aged, 80 and over , Enterobacteriaceae/classification , Enterobacteriaceae/genetics , Environmental Microbiology , Feces/microbiology , Female , Genotype , Hospitals , Humans , Male , Middle Aged , Molecular Typing , Plasmids/analysis , Vietnam/epidemiology , Young Adult
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