[Experience of using genfaxon for treating patients with relapsing-remitting multiple sclerosis in the Russian Federation].

UNLABELLED: Multiple sclerosis (MS) is a chronic autoimmune demyelinating disorder of the central nervous system. Nowadays some disease-modifying drugs (DMD) in the Russian Federation (RF) are biosimilars. Their full spectrum of tolerability and efficacy is to be determined. Here we present results of two retrospective-prospective studies on efficacy and safety of a biosimilar interferon beta-1a (genfaxon) in treatment of MS in the RF. AIMS: determination of safety and efficacy profile of genfaxon in a routine neurological practice in the RF. MATERIALS AND METHODS: Trials were performed in 18 MS centers in the RF. A total of 649 patients aged from 18 to 68 years with the EDSS score no more than 6.0 were treated with genfaxon for 12 months. The first group was comprised of 'naïve' patients without previous history of DMD administration. There were patients in the second group which have already received some of DMD. Statistical analysis was performed with the help of significance criteria (χ-square), t-criteria of Student for analysis of independent samplings. RESULTS: There were no serious adverse events during the period of the study. "Naïve" patients had significantly lower number of adverse events, than patients with previous history of DMD usage. Efficacy results were comparable with results published for the Rebif. CONCLUSIONS: Data, received from the studies show equal efficacy and tolerability of genfaxon compared with original DMD Rebif.

[Significance of changesin the topography of the superior cerebellar artery in the angiographic diagnosis of tumors of the posterior cranial fossa (II)]. / Znachenie izmenenii topografii verkhnei mozzhechkovoi arterii v angiograficheskoi diagnostike opukholei zadnei cherepnoi iamki (soobshchenie II)

Typical shifts of the superior cerebellar artery and its segments were studied in 67 vertebral angiogrammes showing 33 acoustic neurinomas, 7 meningiomas of the cerebellopontile angle, 13 cerebellar hemispheres tumours, 10 pontile tumours and 4 meningiomas of the free margin of the tentorium. The rationale of accounting for the angiographic symptom complexes typical for acoustic neurinomas with varying directions of growth were singled out.

[X-ray anatomy of the superior cerebellar artery (1)]. / Rentgenoanatomiia verkhnei mozzhechkovoi arterii (soobshchenie 1)

The anatomic and angiographic variants of the superior cerebellar artery were studied in 50 macro-preparations of the cerebellum and in 100 normal angiogrammes. The authors distinguish five angiographic variants of the superior cerebellar artery, and emphasize the necessity of their differentiation for proper identification of its branches in interpreting the angiogrammes. Quantitative characteristics is given to the segments of the superior cerebellar artery and their angles, which permits a more precise assessment of the displacement of the superior cerebellar artery.