Dielectric property measurement of human sweat using attenuated total reflection terahertz time domain spectroscopy.

Sweat is one of the essential biofluids produced by the human body, and it contains various physiological biomarkers. These biomarkers can indicate human health conditions such as disease and illness. In particular, imbalances in the concentration of electrolytes can indicate the onset of disease. These same imbalances affect the dielectric properties of sweat. In this study, we used attenuated total reflection terahertz time domain spectroscopy to obtain the frequency-dependent dielectric properties of human sweat in a frequency range from 200 GHz to 2.5 THz. We have investigated the variation of dielectric properties of sweat collected from different regions of the human body, and we have observed that the real and imaginary part of dielectric permittivity decreases with the increase in frequency. A combination of left-hand Jonscher and Havriliak-Negami processes is used to model the results and reveal the presence of relaxation processes related to sodium and calcium ions concentrations. This information may help design novel biosensors to understand the human health condition and provide a hydration assessment.

Optical thin film coated organic nonlinear crystal for efficient terahertz wave generation.

In the process of terahertz (THz) wave generation via optical rectification of infrared femtosecond pulses in a non-linear optical crystal, the power of terahertz wave is directly proportional to the square of the optical pump power. Therefore, high power terahertz wave can be generated using a high power femtosecond laser provided that the crystal has both high laser induced damage threshold and optical non-linear coefficient. However, a significant amount of pump power is lost in this process due to the Fresnel's reflection at the air-crystal boundary. In this paper, we numerically and experimentally demonstrate that the coat of optical thin film called Cytop on the 4-N, N-dimethylamino-4'-N'-methyl-stilbazolium tosylate (DAST) crystal effectively reduces the reflection loss of pump power, thereby increasing the THz wave emission efficiency of the DAST crystal. We found that the average power of THz wave emitted by the thin film coated crystal is about 28% higher than the THz power emitted by the uncoated crystal when an equal amount of laser power is used. The thin film coated DAST crystals can be used not only in terahertz measurement systems but also in optical devices such as modulators and waveguides.

Development of a terahertz wave circular polarizer using a 2D array of metallic helix metamaterial.

We developed a broadband terahertz wave circular polarizer that consists of a two-dimensional (2D) array of three-dimensional metallic helices. Each helix operates in an axial mode of operation where the wavelength of resonance is comparable to the dimensions of the helix. We evaluated the performance of the polarizer using standard terahertz time domain spectroscopy, and we confirmed that the array of helices transmits a circularly polarized terahertz wave with opposite handedness as that of the helices. The polarizer covers the frequency range from 117 GHz to 208 GHz, close to one octave. We obtained the ellipticity of the circularly polarized terahertz wave close to unity in this frequency band.

Influence of delay stage positioning error on signal-to-noise ratio, dynamic range, and bandwidth of terahertz time-domain spectroscopy.

Terahertz time-domain spectroscopy (THz-TDS) employs a mechanical stage to introduce the time delay between pump and probe optical pulses during the sampling process of the time-domain electric field of a terahertz pulse. The positioning error and limited resolution of a mechanical delay stage cause an inaccurate sampling of a terahertz pulse. In this study, we numerically and experimentally investigated the influence of delay stage positioning error on the major characteristics of THz-TDS, such as bandwidth and dynamic range of the system, along with the signal-to-noise ratio (SNR) of the intensity spectra. We demonstrate that the positioning error in the delay stage not only reduces bandwidth and dynamic range of the measurement system but also decreases the SNR of the intensity spectra.

Frequency of the resonance of the human sweat duct in a normal mode of operation.

The applications of terahertz (THz) waves have been increasing rapidly in different fields such as information and communication technology, homeland security and biomedical engineering. However, study on the possible health implications due to various biological effects induced by THz waves is relatively scarce. Previously, it has been reported that the human sweat ducts play a significant role in the interaction of the THz wave with human skin due to its coiled structure. This structure imposes on them the electromagnetic character of a helical antenna. To further understand these phenomena, we investigated the morphological features of human sweat ducts and the dielectric properties of their surrounding medium. Based upon these parameters, we estimated the frequency of the resonance of the human sweat duct in a normal mode of operation and our estimation showed that there is a broad resonance around 228 GHz. This result indicates that careful consideration should be given while designing electronic and photonic devices operating in the sub-terahertz frequency region in order to avoid various effects on human health due to these waves.

Non-destructive drug inspection in covering materials using a terahertz spectral imaging system with injection-seeded terahertz parametric generation and detection.

In 2003, we reported the first-ever development of a spectral imaging system for illicit drugs detection using a terahertz (THz) wave parametric oscillator (TPO) [K. Kawase et al., Opt. Exp. 11(20), 2549 2003]. The system has a dynamic range below four orders of magnitude, which enables it to identify reagents only through thin envelopes using spectral imaging. Recently, we succeeded in developing a high power and high sensitivity THz wave spectral imaging system using injection-seeded THz parametric generation and detection. A dynamic range in excess of 80 dB has been obtained, which is much higher than that of the 2003 system. In this study, the new spectral imaging system successfully identified reagents through thicker material than the thin envelopes used previously.

Terahertz wave three-dimensional computed tomography based on injection-seeded terahertz wave parametric emitter and detector.

We demonstrate a high dynamic range, three-dimensional (3-D) terahertz (THz) wave computed tomography system in which frequency tunable, Fourier transform-limited, high-power THz waves are emitted by an injection-seeded parametric source and ultrasensitive detection of THz waves is accomplished by heterodyne detection. This system covers the frequency range of 0.95 to 2.7 THz and has a maximum dynamic range in excess of nine orders of magnitude, enabling the acquisition of high-resolution 3-D tomographic images of samples with strong THz absorption. As an illustration, we obtained 3-D computed tomographic images of a pencil and a plastic product with an internal defect that demonstrates the potential applications of our imaging system in non-destructive testing and evaluation of industrial products.

Morphology of human sweat ducts observed by optical coherence tomography and their frequency of resonance in the terahertz frequency region.

It is crucial to understand the various biological effects induced by terahertz (THz) electromagnetic waves with the rapid development of electronic and photonic devices operating in the THz frequency region. The presence of sweat glands plays an important role in THz wave interactions with human skin. We investigated the morphological features of sweat ducts using optical coherence tomography (OCT) to further understand such phenomena. We observed remarkable features of the ducts, such as their clear helical structure. The intersubject and intrasubject variations in the diameter of sweat ducts were considerably smaller than the variations in other structural parameters, such as length and number of turns. Based on the sweat duct dimensions and THz dielectric properties of skin measured using terahertz time-domain spectroscopy (THz-TDS), we calculated the resonating frequency of the sweat duct under the assumption of it functioning as a helical antenna. Here, we show that the resonance frequency in the axial mode of operation lies in the THz wave region with a centre frequency of 0.44 ± 0.07 THz. We expect that these findings will further our understanding of the various health consequences of the interaction of THz waves with human beings.

Terahertz wave parametric amplifier.

The importance of terahertz (THz) wave techniques has been demonstrated in various fields, and the range of applications is now expanding rapidly. However, the practical implementation of THz science to solve the real-world problems is restricted due to the lack not only of convenient high power THz wave emitters and sensitive detectors but also of efficient quasi-optical active devices such as amplifiers. In this work, we demonstrate the direct amplification of THz waves in room temperature using magnesium oxide-doped lithium niobate (MgO:LiNbO3) crystals as the nonlinear gain medium. The input THz wave is injected as a seed beam along with the pump beam into the nonlinear crystal and it is amplified by the optical parametric process. We report gain in excess of 30 dB with an input THz pulse energy of less than 1 pJ. We believe that this demonstration will contribute to the convenience and further applicability of THz frequency techniques.