Large language models reshaping molecular biology and drug development.

The utilization of large language models (LLMs) has become a significant advancement in the domains of medicine and clinical informatics, providing a revolutionary potential for scientific breakthroughs and customized therapies. LLM models are trained on large datasets and exhibit the capacity to comprehend and analyze intricate biological data, encompassing genomic sequences, protein structures, and clinical health records. With the utilization of their comprehension of the language of biology, they possess the ability to reveal concealed patterns and insights that may evade human researchers. LLMs have been shown to positively impact various aspects of molecular biology, including the following: genomic analysis, drug development, precision medicine, biomarker development, experimental design, collaborative research, and accessibility to specialized expertise. However, it is imperative to acknowledge and tackle the obstacles and ethical implications involved. The careful consideration of data bias and generalization, data privacy and security, explainability and interpretability, and ethical concerns around responsible application is vital. The successful resolution of these obstacles will enable us to fully utilize the capabilities of LLMs, leading to substantial progress in the fields of molecular biology and pharmaceutical research. This progression also has the ability to bolster influential impacts for both the individual and the broader community.

CASCADE: Context-Aware Data-Driven AI for Streamlined Multidisciplinary Tumor Board Recommendations in Oncology.

This study addresses the potential of machine learning in predicting treatment recommendations for patients with hepatocellular carcinoma (HCC). Using an IRB-approved retrospective study of patients discussed at a multidisciplinary tumor board, clinical and imaging variables were extracted and used in a gradient-boosting machine learning algorithm, XGBoost. The algorithm's performance was assessed using confusion matrix metrics and the area under the Receiver Operating Characteristics (ROC) curve. The study included 140 patients (mean age 67.7 ± 8.9 years), and the algorithm was found to be predictive of all eight treatment recommendations made by the board. The model's predictions were more accurate than those based on published therapeutic guidelines by ESMO and NCCN. The study concludes that a machine learning model incorporating clinical and imaging variables can predict treatment recommendations made by an expert multidisciplinary tumor board, potentially aiding clinical decision-making in settings lacking subspecialty expertise.

From Machine Learning to Patient Outcomes: A Comprehensive Review of AI in Pancreatic Cancer.

Pancreatic cancer is a highly aggressive and difficult-to-detect cancer with a poor prognosis. Late diagnosis is common due to a lack of early symptoms, specific markers, and the challenging location of the pancreas. Imaging technologies have improved diagnosis, but there is still room for improvement in standardizing guidelines. Biopsies and histopathological analysis are challenging due to tumor heterogeneity. Artificial Intelligence (AI) revolutionizes healthcare by improving diagnosis, treatment, and patient care. AI algorithms can analyze medical images with precision, aiding in early disease detection. AI also plays a role in personalized medicine by analyzing patient data to tailor treatment plans. It streamlines administrative tasks, such as medical coding and documentation, and provides patient assistance through AI chatbots. However, challenges include data privacy, security, and ethical considerations. This review article focuses on the potential of AI in transforming pancreatic cancer care, offering improved diagnostics, personalized treatments, and operational efficiency, leading to better patient outcomes.

Efficient healthcare with large language models: optimizing clinical workflow and enhancing patient care.

PURPOSE: This article explores the potential of large language models (LLMs) to automate administrative tasks in healthcare, alleviating the burden on clinicians caused by electronic medical records. POTENTIAL: LLMs offer opportunities in clinical documentation, prior authorization, patient education, and access to care. They can personalize patient scheduling, improve documentation accuracy, streamline insurance prior authorization, increase patient engagement, and address barriers to healthcare access. CAUTION: However, integrating LLMs requires careful attention to security and privacy concerns, protecting patient data, and complying with regulations like the Health Insurance Portability and Accountability Act (HIPAA). It is crucial to acknowledge that LLMs should supplement, not replace, the human connection and care provided by healthcare professionals. CONCLUSION: By prudently utilizing LLMs alongside human expertise, healthcare organizations can improve patient care and outcomes. Implementation should be approached with caution and consideration to ensure the safe and effective use of LLMs in the clinical setting.

Understanding Biases and Disparities in Radiology AI Datasets: A Review.

Artificial intelligence (AI) continues to show great potential in disease detection and diagnosis on medical imaging with increasingly high accuracy. An important component of AI model creation is dataset development for training, validation, and testing. Diverse and high-quality datasets are critical to ensure robust and unbiased AI models that maintain validity, especially in traditionally underserved populations globally. Yet publicly available datasets demonstrate problems with quality and inclusivity. In this literature review, the authors evaluate publicly available medical imaging datasets for demographic, geographic, genetic, and disease representation or lack thereof and call for an increase emphasis on dataset development to maximize the impact of AI models.

Turing test-inspired method for analysis of biases prevalent in artificial intelligence-based medical imaging.

Due to the growing need to provide better global healthcare, computer-based and robotic healthcare equipment that depend on artificial intelligence has seen an increase in development. In order to evaluate artificial intelligence (AI) in computer technology, the Turing test was created. For evaluating the future generation of medical diagnostics and medical robots, it remains an essential qualitative instrument. We propose a novel methodology to assess AI-based healthcare technology that provided verifiable diagnostic accuracy and statistical robustness. In order to run our test, we used a state-of-the-art AI model and compared it to radiologists for checking how generalized the model is and if any biases are prevalent. We achieved results that can evaluate the performance of our chosen model for this study in a clinical setting and we also applied a quantifiable method for evaluating our modified Turing test results using a meta-analytical evaluation framework. His test provides a translational standard for upcoming AI modalities. Our modified Turing test is a notably strong standard to measure the actual performance of the AI model on a variety of edge cases and normal cases and also helps in detecting if the algorithm is biased towards any one type of case. This method extends the flexibility to detect any prevalent biases and also classify the type of bias.