Alopecias: Practical Tips for the Management of Biopsies and Main Diagnostic Clues for General Pathologists and Dermatopathologists.

Accurately diagnosing specific variants of alopecia remains challenging for pathologists, potentially delaying appropriate therapeutic decisions by dermatologists. Issues such as limited knowledge on optimal biopsy types and processing methods add complexity. Understanding the normal histology of hair follicles and their changes throughout the follicular cycle further complicates microscopic evaluation. This paper aims to summarize these characteristics and highlight essential diagnostic clues for pathologists to confidently suggest a diagnosis, therefore playing a key role in alopecia diagnosis. Ongoing education, collaboration with dermatologists, and staying up to date on advancements is crucial for the accurate diagnosis and effective management of different types of alopecia.

[Well differentiated papillary mesothelioma: description of three case reports and review of the literature]. / Mesotelioma papilar bien diferenciado: descripción de tres casos y revisión bibliográfica.

Well Differentiated Papillary Mesothelioma (MPBD) is a very rare neoplasm that mainly affects women of reproductive age. The most common location is the peritoneum and it is an incidental finding, with a generally favorable prognosis. We present three cases diagnosed incidentally, in the course of a surgical intervention of various causes, which presented as peritoneal exophytic lesions not detected in the pre-surgical imaging study. It is important to keep this entity in mind, to differentiate it from other neoplasms with an unfavorable prognosis and evolution, such as Malignant Mesothelioma or primary and metastatic carcinomas. Recent studies give the MPBD a specific immunohistochemical and molecular profile that allow a greater diagnostic precision of the entity.

Mesotelioma papilar bien diferenciado: descripción de tres casos y revisión bibliográfica / Well differentiated papillary mesothelioma: description of three case reports and review of the literature

El mesotelioma papilar bien diferenciado (MPBD) es una neoplasia muy infrecuente que afecta fundamentalmente a mujeres en edad reproductiva. La localización más habitual es el peritoneo y se trata de un hallazgo incidental, con un pronóstico generalmente favorable. Presentamos tres casos diagnosticados de manera incidental, en el trascurso de una intervención quirúrgica de causas diversas, que se presentaron como lesiones exofíticas peritoneales no detectadas en el estudio de imagen prequirúrgico. Es importante tener presente esta entidad para diferenciarla de otras neoplasias de pronóstico y evolución desfavorable, como el mesotelioma maligno o carcinomas primarios y metastásicos. Estudios recientes le confieren al MPBD un perfil inmunohistoquímico y molecular específico que permiten una mayor precisión diagnóstica de la entidad.(AU)

Well Differentiated Papillary Mesothelioma (MPBD) is a very rare neoplasm that mainly affects women of reproductive age. The most common location is the peritoneum and it is an incidental finding, with a generally favorable prognosis. We present three cases diagnosed incidentally, in the course of a surgical intervention of various causes, which presented as peritoneal exophytic lesions not detected in the pre-surgical imaging study. It is important to keep this entity in mind, to differentiate it from other neoplasms with an unfavorable prognosis and evolution, such as Malignant Mesothelioma or primary and metastatic carcinomas. Recent studies give the MPBD a specific immunohistochemical and molecular profile that allow a greater diagnostic precision of the entity.(AU)