ABSTRACT
Fourteen horses (7 treated with orgotein and 7 treated with a placebo) with navicular disease were studied on a double blind basis. All 14 horses had clinical and radiographic evidence of navicular disease. Orgotein and the placebo were administered by juxtabursal injection. Of the 7 orgotein-treated horses, 3 responded but none of the 7 placebo-treated horses responded. The difference was statistically significant (P less than 0.05).
Subject(s)
Anti-Inflammatory Agents/therapeutic use , Foot Diseases/veterinary , Horse Diseases/drug therapy , Metalloproteins/therapeutic use , Osteitis/veterinary , Animals , Anti-Inflammatory Agents/administration & dosage , Bursitis/drug therapy , Bursitis/veterinary , Clinical Trials as Topic , Double-Blind Method , Female , Foot Diseases/drug therapy , Forelimb , Horses , Injections, Intramuscular , Male , Metalloproteins/administration & dosageABSTRACT
Caecal fluid samples collected 8 and 24 hours after carbohydrate overload were quantitatively compared to control samples in terms of aerobic and anaerobic bacteria. Concomitant increases in lactic acid-producing bacteria and decreases in Gram negative bacteria were substantiated during the onset of acute laminitis. Progressive decreases in caecal fluid pH were also quantitated. Although endotoxin assays of caecal fluid and blood were not done, the caecal flora changes suggest its presence during the onset of acute laminitis.
Subject(s)
Cecum/microbiology , Foot Diseases/veterinary , Hoof and Claw , Horse Diseases/microbiology , Animals , Clostridium/isolation & purification , Female , Foot Diseases/microbiology , Horses , Lactobacillus/isolation & purification , Male , Streptococcus/isolation & purificationSubject(s)
Endoscopy/veterinary , Horses , Animals , Endoscopes , Fiber Optic Technology/instrumentationABSTRACT
The characteristics of a series of equine laminitis cases were compared with that of other Equidae examined at the University of Missouri Veterinary Hospital and Clinic during May, 1965 through December, 1971. The model age for ponies with laminitis was 7-9 years and for all other cases the model age was 4-6 years. Also the predominant age for mares was 4-6 years and for males was 7-9 years. After controlling for age and breed differences, there were significantly fewer castrated males among the affected males than expected (P small than 0.02), indicating that hormonal factors may play a role in laminitis. Ponies had a significantly greater risk of laminitis (P smaller than 0.001) and their relative risk was 4.3 times greater than all other Equidae combined. There were more laminitis cases diagnosed during May than during other months.
