ABSTRACT
Polyelectrolytes represent a unique class of polymers abundant in ionizable functional groups. In a solution, ionized polyelectrolytes can intricately bond with oppositely charged counterparts, giving rise to a fascinating phenomenon known as a polyelectrolyte complex. These complexes arise from the interaction between oppositely charged entities, such as polymers, drugs, and combinations thereof. The polyelectrolyte complexes are highly appealing in cancer management, play an indispensable role in chemotherapy, crafting biodegradable, biocompatible 3D membranes, microcapsules, and nano-sized formulations. These versatile complexes are pivotal in designing controlled and targeted release drug delivery systems. The present review emphasizes on classification of polyelectrolyte complex along with their formation mechanisms. This review comprehensively explores the applications of polyelectrolyte complex, highlighting their efficacy in targeted drug delivery strategies for combating different forms of cancer. The innovative use of polyelectrolyte complex presents a potential breakthrough in cancer therapeutics, demonstrating their role in enhancing treatment precision and effectiveness.
Subject(s)
Antineoplastic Agents , Drug Delivery Systems , Neoplasms , Polyelectrolytes , Humans , Polyelectrolytes/chemistry , Neoplasms/drug therapy , Neoplasms/metabolism , Drug Delivery Systems/methods , Antineoplastic Agents/therapeutic use , Antineoplastic Agents/chemistry , Precision Medicine/methodsABSTRACT
UNLABELLED: Malaria is endemic in Gujarat and the adjoining areas like many other parts of the India. Depending upon the environmental conditions different species of malarial parasite are found in different areas. The present study was planned to see the pattern of malarial infection diagnosed at B.J. Desai Trust Hospital, Kheda, Gujarat METHODS: Giemsa stained thick and thin blood films of indoor and outdoor febrile patients sent to the laboratory of B.J. Desai Trust Hospital, Kheda, Gujarat with a suspicion of malaria, were examined. Thick film was examined for the diagnosis of malaria while thin films were seen to know the species. RESULTS: Out of 1994 patients screened, 145 (7.2%) were found infected. Plasmodium vivax was seen in the majority (72.47.2%). Plasmodium falciparum was the second common species detected in 24.1 % cases. Mixed infection was seen in 3.44% cases while Plasmodium malariae and ovale was not seen in any patient. CONCLUSION: Plasmodium vivax was the commonest type of malaria diagnosed at Kheda District in Gujarat, during 2008- 2009.