ABSTRACT
A deep clinical, immunological, microbiological analysis was performed in patients, suffering gastroduodenal ulcer, complicated by hemorrhage. Immunodeficiency state with the signs of autoimmunization was noted in the patients. These changes were most severe in a severe blood loss, the local endoscopic hemostasis instability, high risk of the hemorrhage recurrence occurrence, presence in a periulcer zone mucosa of a conditionally pathogenic and pathogenic microflora with a Klebsiella pneumoniae and Streptococcus beta-haemoliticus predominance. The analysis of the data obtained permits to prognosticate the pathologic process severity course and to improve the program of treatment.
Subject(s)
Peptic Ulcer Hemorrhage/immunology , Peptic Ulcer/immunology , Female , Humans , Klebsiella Infections/complications , Klebsiella Infections/immunology , Klebsiella pneumoniae/isolation & purification , Male , Middle Aged , Peptic Ulcer/microbiology , Peptic Ulcer Hemorrhage/microbiology , Streptococcal Infections/complications , Streptococcal Infections/immunology , Streptococcus/isolation & purificationABSTRACT
Deep clinico-morphological analysis was performed in patients, suffering gastroduodenal ulcer, complicated by hemorrhage. The most severe inflammatory changes were revealed in gastric antrum mucosa. These changes correlated with features of unstable hemostasis and massive blood loss. The data obtained permit to prognosticate the severity course of pathological process and to improve the program of treatment.
