[Association between emotional disorders and ophthalmopathology in residents of the Arkhangelsk region at the age of 60-74 years.]

A study was conducted to investigate the associations of the diseases of the organ of vision and its accessory apparatus with anxiety and depression in the elderly people. The study included 678 participants of the ESSE-RF3 population study in the Arkhangelsk region in the age of 60-74 years. We used a questionnaire, including the hospital scale of anxiety and depression score (HADS), and the assessment of the ophthalmological status. It was found that all the study participants had diseases of the visual organ. Elevated depression scores were associated with sex, age, marital status (being single), and disability, elevated anxiety scores - with sex. The scores on the anxiety scale were on average 25% higher in participants whose visual acuity decreased to 0,5 units, and showed no independent associations with diagnosed ophthalmological diseases. The scores on the depression scale were on average 33% higher in participants with visual acuity 0,5 units, and 22% higher in the presence of retinopathy. In conclusion, anxiety and depression in the elderly people were more associated with visual deficits rather than with the presence of ophthalmological diseases underlying a decrease in functional status.

EFFECT OF SOME IMMUNOMODULATORY DRUGS ON EMBRYONIC DEVELOPMENT OF DANIO RERIO FISH.

At the current stage of healthcare development, the inclusion of immunomodulators in the complex pharmacotherapy of various immunoinflammatory and viral diseases is widely discussed, but due to the lack of sufficient research and a broad evidence base, not all drugs with similar properties are used in medicine. According to the information obtained from the instructions for the use of immunomodulators, it was obtained that the main contraindications to their use include the prescription of children, pregnant women, and women during breastfeeding. In this study, we evaluated the effects of immunomodulatory drugs: aminodihydrophthalazindione sodium and meglumine acridonacetate, on the early developmental stages of Danio rerio (Zebrafish) embryos.

[Dynamics of morbidity in the elderly according to the class of eye and its appendage diseases in the Arkhangelsk region.]

The article describes the trends in the primary morbidity of the elderly by the class of eye disease and its accessory apparatus (H00-H59) in the Arkhangelsk region of Russian Federation from 2018 to 2021, analyzes the features of morbidity by gender, age, form of medical care, nosology according to the Territorial Fund of Compulsory Medical Insurance of the Arkhangelsk region (TFOMS AR), n=418 196. The indicators of primary morbidity of eye diseases in the elderly have a general negative trend, increasing in 2019 during the COVID-19 pandemic. In men, the dynamics of morbidity over five years is lower than in women. Primary morbidity is higher in the group of 70-79 years than in other age groups in relative and absolute values. 90% of primary diagnoses were made during outpatient admission, 6% in a round-the-clock hospital. Among nosologies, the leading ones are lens diseases (H25-H28) - 41,9% and glaucoma (H40-H42) - 20,6%. The data obtained can be used to organize preventive measures, for example, drawing up a plan for medical examination and dispensary observation of the elderly population, as well as to assess sensory deficits when analyzing the level of functionality in the elderly with a comprehensive geriatric assessment.

Altered Processing of Complex Visual Stimuli in Patients with Postconcussive Visual Motion Sensitivity.

BACKGROUND AND PURPOSE: Vestibular symptoms are common after concussion. Vestibular Ocular Motor Screening identifies vestibular impairment, including postconcussive visual motion sensitivity, though the underlying functional brain alterations are not defined. We hypothesized that alterations in multisensory processing are responsible for postconcussive visual motion sensitivity, are detectable on fMRI, and correlate with symptom severity. MATERIALS AND METHODS: Twelve patients with subacute postconcussive visual motion sensitivity and 10 healthy control subjects underwent vestibular testing and a novel fMRI visual-vestibular paradigm including 30-second "neutral" or "provocative" videos. The presence of symptoms/intensity was rated immediately after each video. fMRI group-level analysis was performed for a "provocative-neutral" condition. Z-statistic images were nonparametrically thresholded using clusters determined by Z > 2.3 and a corrected cluster significance threshold of P = .05. Symptoms assessed on Vestibular Ocular Motor Screening were correlated with fMRI mean parameter estimates using Pearson correlation coefficients. RESULTS: Subjects with postconcussive visual motion sensitivity had significantly more Vestibular Ocular Motor Screening abnormalities and increased symptoms while viewing provocative videos. While robust mean activation in the primary and secondary visual areas, the parietal lobe, parietoinsular vestibular cortex, and cingulate gyrus was seen in both groups, selective increased activation was seen in subjects with postconcussive visual motion sensitivity in the primary vestibular/adjacent cortex and inferior frontal gyrus, which are putative multisensory visual-vestibular processing centers. Moderate-to-strong correlations were found between Vestibular Ocular Motor Screening scores and fMRI activation in the left frontal eye field, left middle temporal visual area, and right posterior hippocampus. CONCLUSIONS: Increased fMRI brain activation in visual-vestibular multisensory processing regions is selectively seen in patients with postconcussive visual motion sensitivity and is correlated with Vestibular Ocular Motor Screening symptom severity, suggesting that increased visual input weighting into the vestibular network may underlie postconcussive visual motion sensitivity.

[Clinical and anamnestic data that affect the outcome of rehabilitation on virtual reality in patients with stroke]. / Kliniko-anamnesticheskie dannye, vliyayushchie na iskhod reabilitatsii v virtual'noi real'nosti u patsientov, perenesshikh tserebral'nyi insul't.

OBJECTIVE: To determine the impact of clinical and anamnestic data of stroke patients on the rehabilitation process's outcome in virtual reality (VR). To study parameters of postural stability, gait, daily activity and affective functions during motor training in the immersive high-tech polymodal VR system. MATERIAL AND METHODS: We examined 34 patients (16 women, 18 men, mean age 51.9±12.5) who had a stroke at least 2 weeks ago and had a degree of disability no more than 3 points on the Rankin scale, mainly due to movement disorders. The patients underwent training in the VR system (Grail, Motekforce) for 10 sessions. Before and after the end of the training, the patient's condition was diagnosed, including indicators of motor and daily activities, affective functions, as well as an instrumental assessment of balance and gait in VR. RESULTS: After training up to 62% of patients showed improvements in physical activity, up to 41% - in daily living activities, up to 73% - in the affective sphere. The results of multiple linear regression analysis showed that gender, the type of stroke and the side of the brain lesion are significant predictors for the rehabilitation of postural stability, while the type of stroke and the period of recovery after stroke predict the restoration of the affective sphere. CONCLUSION: Groups of patients stratified by gender, the type of stroke, the side of the brain lesion and recovery period, for whom training in the VR system was most effective, are identified. Based on the results of the study, the authors suggest the criteria of inclusion of VR in the individual rehabilitation program of patients with stroke.

Status epilepticus induced by pentylenetetrazole increases short-term synaptic facilitation in the hippocampus of juvenile rats.

We studied the effect of status epilepticus (SE) on short-term synaptic plasticity. The amplitudes of field potentials in response to extracellular stimulation of the Schaffer collaterals were recorded in hippocampal slices. Subtle modifications were revealed on day 1 after SE, whereas on days 3 and 7 we did not find any differences from the control. These data show that, one day after SE, the probability of a transmitter release in hippocampal synapses decreases that serves as a compensatory mechanism, which prevents seizure activity.

[Health status of military men serving on the North Fleet].

Authors analyzed data characterizing health status of military men serving on the North Fleet, peculiarities of changes in category of fitness for military service in 2002-2011. It was found that 75.1% of conscripts fell into first health group, 20.1%--fell into second health group, 4.8%--fell into third health group. Authors gave detailed characteristics of frequent diseases in military men. Authors formulated organizational solutions, ways of improvement of conscripts' health status.

[The military medical expertise of conscripts and its quality].

The article considers the issues of defects in functioning of conscripting military medical commissions using the analysis of long standing statistical data concerning the changes of category of physical fitness of young conscripts arrived to reinforce the Northern fleet. The study used the materials of reports of the results of medical examination of young reinforcement in 2002-2011. The analysis of 847 disease certificates of conscripts referred to hospital check-up with following health examination by military medical commission of the fleet to reveal diseases blocking the military service admission. The probability model is presented of comorbidity among conscripts to enhance the validity of planning of curative health promoting activities in youth generation. It is proposed during planned control of military commissariats to consider as a separate control elements the analysis of implementation of planned curative health promoting activities concerning conscripts on individual and group levels. The same position is proposed to apply to number of conscripted citizen who were send to military forces but at a later date were admitted as limitedly fitted for military service and not fitted for military service at conscription.

Utility of magnetization transfer T1 imaging in children with seizures.

Failure to detect FCD and similar lesions encountered in patients with tuberous sclerosis can have significant clinical consequences, such as preventing surgical intervention for medically refractory epilepsy and misguiding prognostic information regarding cognitive development. Here, we show the beneficial effects on detection of FCD and cortical tubers when using a magnetization transfer T1 sequence for children with seizures who underwent MR imaging at our institution.

[Variation of mini- and microsatellite DNA repeats in parthenogenetic lizard Darevskia armeniaca as revealed by DNA fingerprinting analysis]. / Fingerprintnyi analiz variabel'nosti mini- i mikrosatellitnykh povtorov DNK u partenogeneticheskikh iashcherits Darevskia armeniaca.

Population and family samples of two morphological forms (mutant and normal with respect to dorsal color) of pathogenetic lizard Darevskia armeniaca were examined by means of DNA fingerprinting using M13 mini- and (GATA)n and (TCC)n microsatellite DNA markers. The morphological forms examined were characterized by clonally inherited, species-specific patterns of the DNA markers, which were different from the species-specific DNA fingerprints of the other parthenogenetic species of the genus Darevskia (D. dahli. D. unisexualis, and D. rostombekovi). The mean index of similarity (S) obtained for a sample of 36 individuals from three isolated populations using three types of DNA markers was 0.966. This was similar to the variability level observed in D. dahli (0.962) (P > 0.05), but higher than that in D. unisexualis (0.950) (P < 0.05) and D. rostombekovi (0.875) (P < 0.01). Inheritance of M13 minisatellite and (TCC)n microsatellite DNA markers in the F1 offspring of parthenogenetic lizards was examined. It was shown that variability and clonal diversity of the fingerprint phenotypes observed in the populations and families of D. armeniaca could be at least partly explained by RFLP mutations in microsatellite repeats.