1.
Neurology
; 31(11): 1440-4, 1981 Nov.
Article
in English
| MEDLINE
| ID: mdl-7198191
ABSTRACT
Sera of myasthenic patients containing anti-AChR antibodies increase the rate of degradation of mammalian AChR. This phenomenon, antigenic modulation (AMd), was tested on AChR of rat myotubes in serum from 48 myasthenic patients. Sixty-six percent of the sera increased AChR degradation. AMd activity was higher in more severely affected patients, paralleled clinical evolution in individual patients, and was related to AChR-antibody titer. Steroid treatment and thymectomy did not affect AMd activity. Patients who had a thymoma always had greater AMd activity.
Subject(s)
Antibodies/analysis , Myasthenia Gravis/immunology , Receptors, Cholinergic/immunology , Adolescent , Adult , Aged , Animals , Cells, Cultured , Child , Female , Half-Life , Humans , Male , Middle Aged , Muscles/metabolism , Myasthenia Gravis/complications , Myasthenia Gravis/diagnosis , Rats , Rats, Inbred Strains , Receptors, Cholinergic/metabolism , Thymoma/complications , Thymus Neoplasms/complications
2.
Pharmacol Res Commun
; 12(6): 611-7, 1980 Jun.
Article
in English
| MEDLINE
| ID: mdl-7403233
3.
Neuroscience
; 5(2): 313-8, 1980.
Article
in English
| MEDLINE
| ID: mdl-7374944
4.
Lancet
; 1(8054): 46-7, 1978 Jan 07.
Article
in English
| MEDLINE
| ID: mdl-74527