1.
Ann Ital Med Int
; 3(3): 213-9, 1988.
Article
in Italian
| MEDLINE
| ID: mdl-2856354
Subject(s)
Hemorrhage/prevention & control , Heparin, Low-Molecular-Weight/therapeutic use , Pulmonary Embolism/drug therapy , Thrombophlebitis/drug therapy , Adult , Aged , Drug Administration Schedule , Female , Hemorrhage/chemically induced , Heparin/adverse effects , Heparin, Low-Molecular-Weight/administration & dosage , Humans , Risk Factors
2.
Eur J Clin Pharmacol
; 32(3): 309-11, 1987.
Article
in English
| MEDLINE
| ID: mdl-3595704
ABSTRACT
The influence of a single low dose of verapamil (80 mg) on the serum levels of digoxin (single dose of 0.5 mg) was studied in 6 patients with hepatic cirrhosis and in 6 healthy volunteer controls. In the cirrhotic patients verapamil increased the peak serum level and the total AUC of digoxin by 98% and 32%, respectively. There was an associated 23% decrease in the renal digoxin clearance. In normal subjects only marginal alterations in digoxin kinetics were observed following verapamil administration. The results indicate that cirrhosis magnifies the influence of verapamil on digoxin kinetics.
