ABSTRACT
PURPOSE: To assess the prevalence and characteristics of psychiatric drug use in pregnancy. METHODS: A prospective observational study was performed on a total of 1332 consecutive women admitted for delivery, during a 3 months period, in the public obstetric services of Tenerife Island (covering a population of 1 000 000 inhabitants). RESULTS: Less than 4% (3.6%) of the women recognised having a psychiatric disorder, and only 2.5% were receiving psychiatric drug treatment at the moment they knew they were pregnant; of those, 68.7% introduced substantial modifications in their treatment at that moment, 47.9% did not report any change with respect to the period before pregnancy and 35.4% recognised that their mood was worse than previously. Although patients affected by a psychiatric disorder registered a higher rate of abdominal delivery, no differences in delivery or obstetric complications were found between women with and without psychiatric illness or in relation to psychiatric drug treatment. CONCLUSIONS: Compared to the literature, the studied population shows a lower rate of psychiatric problems and pharmacological treatment. This might reflect underrecognition or undertreatment.
Subject(s)
Drug Utilization Review/statistics & numerical data , Pregnancy Complications/drug therapy , Psychotropic Drugs/therapeutic use , Surveys and Questionnaires , Adolescent , Adult , Antidepressive Agents/administration & dosage , Antidepressive Agents/therapeutic use , Benzodiazepines/therapeutic use , Cesarean Section/statistics & numerical data , Depressive Disorder/drug therapy , Drug Utilization Review/methods , Feeding and Eating Disorders/drug therapy , Female , Humans , Infant, Newborn , Lithium Compounds/therapeutic use , Middle Aged , Obsessive-Compulsive Disorder/drug therapy , Paroxetine/therapeutic use , Pregnancy , Pregnancy Outcome , Prospective Studies , Spain , Treatment Outcome , Withholding Treatment/statistics & numerical dataABSTRACT
AIM: To construct normal standards for fetal neurobehavioral development using longitudinal observations through all trimesters by four-dimensional sonography. SUBJECT AND METHODS: A group of 100 healthy normal singleton pregnancies were recruited for longitudinal 4D US examinations to evaluate fetal neurodevelopmental parameters between 7 to 40 weeks' gestation. Variables of maternal and fetal characteristics including gestational age, eight fetal movements patterns in the first trimester and 14 parameters of fetal movement and fetal facial expression patterns recorded thereafter for the construction of fetal neurological charts. RESULTS: Measurement of 7 parameters in the first trimester and 11 parameters in the second and third trimesters correlated with gestational age (P<0.05). Those parameters have been followed longitudinally through all trimesters and showed increasing frequency of fetal movements during the first trimester. A tendency towards decreased frequency of facial expressions and movement patterns with increasing gestational age from second to third trimesters has been noticed. CONCLUSION: With 4D sonography, it is possible to quantitatively assess normal neurobehavioral development. There is urgent need for further multicentric studies until a sufficient degree of normative data is available and the predictive validity of the specific relationship between fetal neurobehavior and child developmental outcome is better established.
Subject(s)
Fetal Development , Fetal Movement , Image Enhancement/methods , Ultrasonography, Prenatal/methods , Brain/embryology , Brain/physiology , Facial Expression , Female , Gestational Age , Humans , Longitudinal Studies , Pregnancy , Pregnancy TrimestersABSTRACT
No disponible
