ABSTRACT
The present MAC for ethylenediamine (2 mg/cu m) does not match up-to-date requirements of industrial medicine and requires experimental analysis. Using contemporary methodic approaches, the authors studied toxicodynamics of ethylenediamine, revealed parameters of its toxicity and jeopardy. Biologic effects of ethylenediamine are irritation, allergic signs and changes in central nervous system. Chronic inhalation experiment helped to determine the MAC for ethylenediamine at 0.3 mg/cu m, 2nd jeopardy grade, that requires labels "Allergen" and "Skin protection required".
Subject(s)
Ethylenediamines , Allergens , Animals , Central Nervous System/drug effects , Ethylenediamines/toxicity , Guinea Pigs , Lethal Dose 50 , Maximum Allowable Concentration , Mice , Models, Theoretical , Rabbits , Rats , Skin/drug effectsABSTRACT
Using chamber for adjustable mode and dosing apparatus, the authors studied conditions of imidazolines' condensation from the air into 60% ethanol, to paper filters of "white tape" type, to analytic filters of AFA-HP type, into a shell with ultrathin layer of sorbent (2.7% sulfuric acid in 20% solution of glycerine in water). The best results were provided by experiments using the paper filter of "white tape" type and absorbing objects filled with 60% ethanol and containing spongy plate. Rate of the air pumping equalled 2-3 l/min and 0.5 l/min respectively.
