ABSTRACT
The analysis of publications shows that diverse multiple factors can induce changes in taste sensitivity and the main irritants are the chemicals of different types. However, the study of the effect of the components of dental structural materials on the state of lingual mucosa, in particular, taste sensors, has not been fully elucidated to date. The purpose of the paper was the study of the effect of monomer of the "Ftoraks" base acrylic resin on the state of the rats' lingual mucosa within 2-4 weeks after its impact. The previous paper [5] presents the findings of the study on the impact of the monomer of the "Ftoraks" base acrylic resin on the state of the rats' lingual mucosa in the early period (1 to 7 days) and its subsequent regeneration. The studies have found that the greatest changes in the lingual mucosa occur on day 3 and 7 after the application of monomer, and are of erosive-inflammatory origin. Regeneration of the lingual epithelium is delayed. The studies confirm that the monomer of acrylic resin causes a number of pathological changes in the mucous membrane and muscles of the rat tongue, the nature of which varies depending on the duration of its impact. On day 14 in the lingual mucosa the destructive processes are significantly delayed, substituting for the sclerotic processes in the proper plate and atrophic processes, observed, first of all, in the papillae of the tongue. It is appropriate to assume that such changes in the papillae will lead to violation of the taste reception, first of all, in the areas of lateral surfaces of the body of the tongue and in the root area. At the same time, it should be noted that at the end of the experimental period (on day 28 of the contact of the monomer with the lingual mucosa), in the mucous membrane of the tongue, along with atrophic and sclerotic processes, the destructive changes and inflammatory reaction are evident. We hypothesize that this may indicate about partial recovery of taste sensitivity due to the decrease in the number of gustatory buds, taste papillae of different types and the increase in the period of their regeneration.
Subject(s)
Acrylic Resins/pharmacology , Mouth Mucosa/drug effects , Resins, Synthetic/pharmacology , Taste Buds/drug effects , Animals , Lymphocytes/drug effects , Lymphocytes/ultrastructure , Macrophages/drug effects , Macrophages/ultrastructure , Mast Cells/drug effects , Mast Cells/ultrastructure , Microscopy , Mouth Mucosa/cytology , Mouth Mucosa/physiology , Muscle Fibers, Fast-Twitch/drug effects , Muscle Fibers, Fast-Twitch/ultrastructure , Rats , Rats, Wistar , Regeneration/physiology , Taste Buds/physiology , Taste Buds/ultrastructure , Taste Perception/drug effects , Taste Perception/physiologyABSTRACT
Twenty isolates of Fusarium graminearum have been isolated from infested grain. When laying hens were fed with biomass of most isolates, the quality of eggs deteriorated. It was found that all the isolated produced a yellow-orange metabolite with an antibiotic activity against mycelial fungi and yeasts. The metabolite was identified by physico-chemical methods as the dimeric naphthoquinone aurofusarin. The production of the other mycotoxins zearalenone and deoxynivalenol by the fungal isolates did not evoke the syndrome of egg quality deterioration.
