[Correlation between HLA antigens and immune status in dust-induced lung diseases in workers of machine-building industry]. / Vzaimosviaz' mezhdu antigenami sistemy HLA i sostoianiem immuniteta pri pylevoi patologii legkikh u rabochikh mashinostroitel'noi promyshlennosti.

Simultaneous study of immune state and HLA-testing was conducted for 73 patients with pneumoconiosis and 52 sufferers from dust bronchitis. The HLA antigens appeared to correlate with immune disorders in those diseases. The study revealed differences in the HLA antigens causing immune changes in pneumoconiosis and dust bronchitis. Those differences corresponded to differences between the markers of propensity to those diseases. Thus, the authors assume that formation of pneumoconiosis or dust bronchitis could depend on genetically determined variants of immune disorders.

[The immune system in dust-induced bronchitis]. / Immunnaia sistema pri pylevom bronkhite.

Studies of the immunity in 233 patients with dust-induced bronchitis (DIB), engaged in machine building, have revealed essential shifts in the T and B immunity systems, that were related to the severity and clinical features of the disease. The authors have set up the criteria for defining the normal range of values and the range of immunologic values characteristic of DIB; this helped detect the disordered immunity parameters in each of the examined patients. A method for the diagnosis of the immunity disorders in DIB patients is suggested, making use of just two characteristics, the per cent share of active T and B lymphocytes and their ratio, this essentially simplifying and accelerating the investigation.

[Immune reactivity in pneumoconiosis and coniotuberculosis in machine builders]. / Immunologicheskaia reaktivnost pri pnevmokonioze i koniotuberkuleze u mashinostroitelei.

Immune status was examined in 231 patients facing pneumoconiosis and coniotuberculosis so as to observe a dependence on pneumoconiosis type (silicosis, electric welder's pneumoconiosis), severity of the process, activity of tuberculosis. Markedly changed T and B immunity, having already appeared at initial stage of the disease, were revealed. Those changes due to the tuberculosis activity were characterized by lymphocytosis, marked functional immaturity of T lymphocytes, depressed B lymphocytes count, elevated serum Ig level.

[Use of chlotazol as an immunomodulating agent in chronic bronchitis]. / Primenenie khlotazola v kachestve immunomoduliruiushchego sredstva pri khronicheskom bronkhite.

A positive immunomodulatory effect was found in chronic bronchitis patients examined immunologically before and after treatment including chlotazol. T- and B-cell immunity recovered, clinical condition of the patients improved. A combination of known antimicrobial and antiinflammatory effects with an uncovered immunomodulatory one made chlotazol a valuable modality in the treatment of chronic bronchitis associated with secondary immune deficiency.