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CNS Oncol ; 8(2): CNS34, 2019 06.
Article in English | MEDLINE | ID: mdl-30855176

ABSTRACT

Aim: Genomically matched trials in primary brain tumors (PBTs) require recent tumor sequencing. We evaluated whether circulating tumor DNA (ctDNA) could facilitate genomic interrogation in these patients. Methods: Data from 419 PBT patients tested clinically with a ctDNA NGS panel at a CLIA-certified laboratory were analyzed. Results: A total of 211 patients (50%) had ≥1 somatic alteration detected. Detection was highest in meningioma (59%) and gliobastoma (55%). Single nucleotide variants were detected in 61 genes, with amplifications detected in ERBB2, MET, EGFR and others. Conclusion: Contrary to previous studies with very low yields, we found half of PBT patients had detectable ctDNA with genomically targetable off-label or clinical trial options for almost 50%. For those PBT patients with detectable ctDNA, plasma cfDNA genomic analysis is a clinically viable option for identifying genomically driven therapy options.


Subject(s)
Biomarkers, Tumor/genetics , Brain Neoplasms/genetics , Circulating Tumor DNA/genetics , Glioblastoma/genetics , Adolescent , Adult , Aged , Aged, 80 and over , Biomarkers, Tumor/blood , Brain Neoplasms/blood , Brain Neoplasms/diagnosis , Brain Neoplasms/pathology , Child , Child, Preschool , Circulating Tumor DNA/blood , Female , Glioblastoma/blood , Glioblastoma/diagnosis , Glioblastoma/pathology , Humans , Male , Middle Aged , Mutation , Prognosis , Sequence Analysis, DNA , Young Adult
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