The level of aberrant cells in various tissues of bank vole depending on doses and radionuclide balance in organism.

A regression analysis shows the direct linear relation between 137Cs accumulation in rodents and the level of aberrant cells. For 90Sr this trend was negative. The dose relationship was the same with 137Cs. The trends were negative 1 month later after feeding of animals with clean food. Correspondingly the dose relationship was also negative. The levels of cells with apoptosis features were different in animals from the control and the radiocontaminated sites. The analysis has revealed the correlation between the 90Sr content in animal body and the number of alveolar macrophages containing micronuclei. The relationship was revealed between the 137Cs content in the animal body and the number of intestinal epithelial cells with micronuclei.

[Chromosome aberrations in different tissues of the murine rodents and amphibians from radionuclide-contaminated regions of Belarus]. / Khromosomnye aberratsii v razlichnykh tkaniakh myshevidnykh gryzunov i amfibii iz zagriaznennykh radionuklidami raionov Belarusi.

Cytogenetic investigations of amphibian and rodent populations from the contaminated by radionuclides regions of Belarus was conducted. A significant increase in the levels of cytogenetic anomalies in bone marrow cells and intestinal epithelium of amphibians and rodents, the levels of alveolar macrophages of rodents, and micronuclei in peripheral blood erythrocytes of amphibians was revealed. Presence of chromosome type aberrations indicates that radiation as a mutagenic factor was involved. No strict relationship between the levels of contamination of the area and levels of cytogenetic anomalies was found.

[The radiosensitivity and thermoresistance of the cells of substrains of rhabdomyosarcoma RA-2 in rats]. / Radiochuvstvitel'nost' i termoustoichivost' kletok subshtammov rabdomiosarkomy RA-2 krys.

The data obtained show that clonogenic RA-2T cells are 2-3 times more thermoresistant than clonogenic cells of the original thermosensitive RA-2T strain as estimated by D0 value upon heating up to 43-45 degrees C. After X-irradiation of rat rhabdomyosarcoma, a decrease in the capacity of forming pulmonary colonies is more pronounced in cells of the thermosensitive RA-2 strain cells than in those of the thermoresistant strain RA-2T (D0 = 1.6 Gy and D0 = 2.4 Gy, respectively). In all appearance, within one and the same tumor cell population, the hereditarily thermoresistant cells are more radioresistant than the thermosensitive ones.

[Changes in primary heat sensitivity of rhabdomyosarcoma PA-2 cells in rats during selection for heat resistance]. / Izmenenie pervichnoi termoustoichivosti kletok rabdomiosarkomy PA-2 krys v protsesse selektsii na termorezistentnost'.

Using the technique of multistep selection, a thermoresistant substrain (TR RA-2T45) was obtained from a rhabdomyosarcoma RA-2 strain. The cells of this substrain retain the ability to form lung metastasis after a 20 minute treatment at 45 degrees C in vitro. The selection of cells for their ability to retain their reproduction activity is accompanied by the increase in their primary thermoresistance. The increased reproductive thermoresistance and primary thermoresistance of the selected cells is hereditary stabilized. Cells of both original strain and its substrain are capable of thermal tolerance, which makes perspective the selection for further increase in thermoresistance in RA-2T4t cell population.