ABSTRACT
PURPOSE: This study was designed to assess the impact of technical factors on functional outcomes and complications in patients undergoing restorative proctocolectomy for familial adenomatous polyposis. METHODS: This was a descriptive study on 189 patients undergoing restorative proctocolectomy in a single tertiary referral center between 1977 and 2003. Primary outcomes were major complications, pouch function, and neoplastic transformation in the anal transitional zone. RESULTS: Pouch construction was J-reservoir (60 percent), W-reservoir (34 percent), or S-reservoir (6 percent), with double-stapled (31 percent) or handsewn anastomosis with mucosectomy (69 percent). Overall pouch survival was 96 percent at five years and 89 percent at ten years, with no differences according to pouch design or anastomotic technique. The incidence of pelvic sepsis was unaffected by anastomotic technique (stapled vs. handsewn; 12 vs. 13 percent) or type of reservoir (J- vs. W- vs. S-pouch; 16 vs. 9 vs. 10 percent). Fistula formation was independent of anastomotic technique (stapled vs. handsewn; 8 vs. 8 percent) and type of reservoir (J- vs. W- vs. S-pouch; 9 vs. 7 vs. 0 percent). The night-time and 24-hour bowel frequencies were similar with the two anastomotic techniques and types of reservoirs. The incidence of polyps at the anal transitional zone was lower with handsewn than with stapled anastomosis (19 vs. 38 percent; P=0.047). CONCLUSIONS: Restorative proctocolectomy in patients with familial adenomatous polyposis has good functional outcomes and an acceptable rate of complications, which are independent of choice of technique. Handsewn ileoanal anastomosis with mucosectomy seems to reduce the incidence of subsequent neoplasia in the anal transitional zone but does not eliminate the risk of cancer.
Subject(s)
Adenomatous Polyposis Coli/surgery , Proctocolectomy, Restorative/methods , Adult , Female , Follow-Up Studies , Humans , Incidence , Length of Stay , Male , Neoplasm Recurrence, Local/epidemiology , Postoperative Complications/epidemiology , Retrospective Studies , Risk Factors , Time Factors , Treatment OutcomeABSTRACT
BACKGROUND AND OBJECTIVE: Thyroid carcinomas thymus-like differentiation (CASTLE) are rare. The aim of this paper is to address a valid diagnostic and therapeutic protocol for these tumours using three exemplary cases and the previously published literature. METHODS: The routine use of Magnetic Resonance Imaging (MRI) in all cases of unclear thyroid fine needle aspiration cytology (FNAC) or in cases of multiple neck masses. RESULTS: Three cases of thyroid CASTLE tumours, finally confirmed by histology, are evaluated. All three patients remain in good conditions after an aggressive surgical approach followed by radiotherapy. CONCLUSIONS: MRI should be routinely used in cases of unclear FNAC or multiple neck masses, Surgery and radiotherapy are effective to manage thyroid CASTLE tumours.
