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Ukr Biokhim Zh (1999) ; 75(6): 87-94, 2003.
Article in Ukrainian | MEDLINE | ID: mdl-15143523

ABSTRACT

The long-term influence of low X-ray irradiation increases lipid peroxidation (LP) in radiosensitive (bone marrow, enterocytes of small intenstine) and in relatively radioresistant blood cells (erythrocytes). The activation of antioxidant system enzymes in observed cells does not decrease LP intensity. We concluded that additional administration of alpha-tocopherol provided the decrease of the first and end products of LP in the observed tissues mostly in the beginning of the experiment. Antioxidant effect of the preparation is more significant in cells with high proliferative activity but normal activity of enzymes was not determined.


Subject(s)
Antioxidants/therapeutic use , Enterocytes/enzymology , Erythrocytes/enzymology , Intestine, Small/enzymology , Radiation Injuries, Experimental/prevention & control , Vitamin E/therapeutic use , Animals , Bone Marrow Cells/drug effects , Bone Marrow Cells/enzymology , Bone Marrow Cells/radiation effects , Catalase/metabolism , Dose-Response Relationship, Radiation , Enterocytes/drug effects , Enterocytes/radiation effects , Erythrocytes/drug effects , Erythrocytes/radiation effects , Glutathione Peroxidase/metabolism , Glutathione Reductase/metabolism , Intestine, Small/drug effects , Intestine, Small/radiation effects , Lipid Peroxides/blood , Radiation Dosage , Radiation Injuries, Experimental/blood , Radiation Injuries, Experimental/enzymology , Rats , Superoxide Dismutase/metabolism , X-Rays
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