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ABSTRACT

The present studies were undertaken to analyze the factors regulating 3-hydroxycinnamic acid-induced apoptosis and cell cycle arrest. Treatment of human cervix HeLa cells with 3-hydroxycinnamic acid induced apoptosis and G0/G1-phase arrest. The percentage of apoptosis induced by 3-hydroxycinnamic acid in HeLa cells was increased with incubation time. The results also demonstrated that 3-hydroxycinnamic acid increased the expression of p53, caspase-3, Bax and cyclin B. These results demonstrated that 3-hydroxycinnamic acid induced apoptosis through p53- and caspase-3-dependent pathways.

Subject(s)

Adenocarcinoma/pathology , Apoptosis/drug effects , Coumaric Acids/pharmacology , G1 Phase/drug effects , Resting Phase, Cell Cycle/drug effects , Uterine Cervical Neoplasms/pathology , Adenocarcinoma/drug therapy , Adenocarcinoma/metabolism , Adult , Caspase 3 , Caspases/metabolism , Cell Proliferation/drug effects , Cell Survival/drug effects , Cyclin B/metabolism , DNA Fragmentation/drug effects , Dose-Response Relationship, Drug , Female , HeLa Cells/drug effects , HeLa Cells/metabolism , HeLa Cells/pathology , Humans , Proto-Oncogene Proteins c-bcl-2/metabolism , Tumor Suppressor Protein p53/metabolism , Uterine Cervical Neoplasms/drug therapy , Uterine Cervical Neoplasms/metabolism , bcl-2-Associated X Protein

ABSTRACT

Subject(s)

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