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A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo.
Essex-Lopresti, Angela E; Boddey, Justin A; Thomas, Richard; Smith, Martin P; Hartley, M Gill; Atkins, Timothy; Brown, Nat F; Tsang, Chuk Hai; Peak, Ian R A; Hill, Jim; Beacham, Ifor R; Titball, Richard W.
Infect Immun ; 73(2): 1260-4, 2005 Feb.
Article in English | MEDLINE | ID: mdl-15664977

ABSTRACT

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.


Subject(s)
Bacterial Adhesion/physiology , Burkholderia pseudomallei/metabolism , Fimbriae Proteins/metabolism , Fimbriae, Bacterial/metabolism , Animals , Bacterial Adhesion/genetics , Burkholderia pseudomallei/genetics , Burkholderia pseudomallei/pathogenicity , Caenorhabditis elegans/metabolism , Caenorhabditis elegans/microbiology , Cells, Cultured , Epithelial Cells/metabolism , Epithelial Cells/microbiology , Fimbriae, Bacterial/genetics , Humans , Mice , Time Factors
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