[Increased myelopepoxidase activity is a risk factor for ishemic heart disease in patients with diabetes mellitus].

Using previously developed spectro-photonmetrical method (Bioorg. Khim. 2009. V. 35. pp. 629-639), a significant increase of myeloperoxidase (MPO) activity was found in blood plasma of patients with type 2 diabetes mellitus (DM2) without of cardiovascular complications, as well as with ischemic heart disease (IHD). Plasma MPO concentration measured by an enzyme-linked immunosorbent assay was significantly higher only in blood plasma of patient with DM2 and IHD. A direct and significant correlation between MPO activity and MPO concentration was observed only in blood plasma samples from healthy donors. Increased MPO activity did not correlate with MPO concentration in blood plasma of patients with DM2 and DM2 with IHD. Taken together, these results highlight the necessity for studying of the MPO role in the development of pathological processes to determine both the amount of enzyme and its peroxidase activity in the blood. The proposed approach gives comprehensive information about the relationship between MPO activity and MPO concentration in patient blood. Since the high concentration of MPO is a diagnostically significant parameter in the prediction of endothelial dysfunction and cardiovascular disease development, the obtained results evidence the contribution of MPO-dependent reactions in cardiovascular complications associated with diabetes. MPO activity may serve as an additional diagnostic criterion for determination of risk of IHD in DM patients.

[The role fo collateral circulation in the course of coronary heart disease: 10-year clinical and angiographic follow-up]. / Rol' kollateral'nogo krovoobrashcheniia v techenii ishemicheskoi bolezni serdtsa (rezul'taty desiatiletnego kliniko-angiograficheskogo nabliudeniia).

The paper presents the results of a 10-year prospective follow-up of 59 patients with coronary heart disease (CHD) concurrent with functional classes II-IV angina pectoris. Coronarography was made in all the patients whose coronary arteries and collateral blood flow were assessed. The experimental group comprised 37 patients with CHD and collateral circulatory insufficiency. The control group included 22 patients with effective collateral circulation. The experimental group showed a worse prognosis than did the control one. Myocardial infarction developed in 54 and 27% of cases, coronary heart disease mortality was 29.7 and 9% in the experimental and control groups, respectively. Effective collateral circulation is a prerequisite of successful surgical myocardial infarction.

[Diagnostic potentials of a precordial mapping method in patients with acute and chronic forms of ischemic heart disease]. / Diagnosticheskie vozmozhnosti metoda prekordial'nogo kartirovaniia u bol'nykh s ostroi i khronicheskimi formami ishemicheskoi bolezni serdtsa.

Diagnostic potentialities of modified 27 and 30 precordial ECG-leads were defined for rapid assessment of the coronary blood flow in patients with acute myocardial infarction (AMI) and chronic coronary heart disease during an acute pharmacological test. ECG criterita of limiting AMI size and ECG criteria of the ischemic reaction during the pharmacological xantinol nicotinate test were defined. It was proved that the use of multiple ECG leads raised the sensitivity of the ECG method in the diagnosis of AMI by 13.6% and in the diagnosis of stenosing atherosclerosis of the coronary arteries by 12.9%.

[Effect of treatment with trental on indicators of peripheral hemodynamics and blood lipid level in patients with arteriosclerosis of the lower extremities]. / Vliianie kursovogo lecheniia trentalom na pokazateli perifericheskoi gemodinamiki i soderzhanie lipidov v krovi bol'nykh aterosklerozom arterii nizhnikh konechnostei.

Rheovasographic parameters of lower-limb regional blood flow, and lipid metabolism were assessed in 35 trental-treated patients with lower-limb arterial atherosclerosis and in 40 normal subjects. Blood volume increased, and vascular tonicity and elasticity improved in the affected limbs following treatment. Activated transcapillary metabolism is reflected in increased capillary permeability and lymph microflow rate, accompanied with a transition of plasma cholesterol ethers from liquid crystalline to isotropic state.

[Use of the Complamin test for diagnosing stenosing atherosclerosis in the coronary arteries]. / Primenenie komplaminovoi proby dlia diagnostiki stenoziruiushchego ateroskleroza venechnykh arterii serdtsa.

A pharmacologic loading test with xanthinol nicotinate was used unprecedentedly to detect occlusion of coronary arteries. Complamine was administered intramuscularly in a dose of 7.5 mg per 1 kg of the patient's weight. Twenty-nine patients with coronarographically-confirmed coronary arterial stenosis and twenty patients with cardialgias of non-coronary origin were investigated. Clinical and electrocardiographic criteria were worked out for the assessment of the complamine test results. The sensitivity and specificity of the test were estimated at 93.1 and 98%, respectively. The complamine test is recommended as part of combined screening for stenosed coronary arteries in patients with coronary heart disease.