ABSTRACT
A new original drug dimetpramid injected per os into mice and rats exhibits moderate toxicity, exerts a weak irritating action on the mucous membranes. The drug is capable of penetrating via the unaffected skin, producing systemic effects. With all routes of administration the drug may have a moderate inhibitory action on ovarian function and the manifestation of the hypotensive effect.
Subject(s)
Antiemetics/toxicity , Benzamides/toxicity , Animals , Antiemetics/administration & dosage , Benzamides/administration & dosage , Dose-Response Relationship, Drug , Estrus/drug effects , Female , Guinea Pigs , Lethal Dose 50 , Mice , Rabbits , Rats , Time FactorsABSTRACT
It has been demonstrated that dimethpramide exerted an adverse effect on the sexual glands of female rats. It provoked an inhibition of ovarian function (derangement of cycling rhythmicity, the loss of individual cycle stages) and depletion of energy resources of the uterus (drop of glycogen content). The reduction of the gonadotropic activity of the pituitary was also observed.
Subject(s)
Antiemetics/toxicity , Benzamides/toxicity , Reproduction/drug effects , Administration, Oral , Animals , Carbohydrate Metabolism , Dose-Response Relationship, Drug , Estrus/drug effects , Female , Ovary/drug effects , Pituitary Gland/drug effects , Pregnancy , Rats , Uterus/drug effects , Uterus/metabolismABSTRACT
Two equations of the dose-time-effect dependence during repeated intramuscular injections of testosterone esters are presented. The equation coefficients characterizing both properties of the drugs injected and individual features of the organs exposed to their action are interpreted. Moreover, two equations for calculating duration of the mitotic cycle of the test organ cells are given.
Subject(s)
Models, Biological , Testosterone/administration & dosage , Animals , Castration , Dose-Response Relationship, Drug , Injections, Intramuscular , Male , Mathematics , Mitosis/drug effects , Rats , Time Factors , Tissue DistributionABSTRACT
Materials of an experimental study on allergenic properties of prolonged-action sulfanilamides and their semi-products are presented. Investigations involved the use of express-methods with intradermal administration of the substance into the ear and introduction of the agents together with the Freind adjuvant into the hind paw pad of a guinea pig. Experiments ascertained satisfactory dermal-allergic responses to the introduction of allergens differing in their strength by employing the above methods, as express ones for primary evaluation tof allergenic properties of drugs and their semi-products in conducting toxicological investigations.
