Epidemiologic Characteristics of Children with Blood Lead Levels ≥45 µg/dL.

OBJECTIVES: To identify risk factors and describe outcomes for children newly identified with blood lead levels (BLLs) ≥45 µg/dL in New York City (NYC) during 2004-2010 to promote timely identification as well as inform clinical practice and public health policy. STUDY DESIGN: Inclusion criteria were residence in NYC and an elevated confirmatory venous test within 2 weeks of the initial BLL ≥45 µg/dL. Data collected during case coordination of these children were linked with blood testing data and home inspection reports. Children with BLLs ≥45 µg/dL also were compared with the general population of children younger than 18 years of age in NYC. RESULTS: A total of 145 children <18 years of age were newly identified with BLLs ≥45 µg/dL. The mean age was 3.83 years, and the median time for BLL to decline below 10 µg/dL was 3.26 years. Major reported risk factors were eating paint (36%), spending time outside the US (34%), having a developmental delay (27%), using imported products (26%), being foreign born (14%), being of Pakistani descent (12%), eating soil (5%), and having sickle cell disease (4%). Compared with the age-standardized NYC population, cases were more likely to be Asian or black and live in housing built before 1940. CONCLUSIONS: Although the incidence of lead poisoning has declined in the US, severe cases still occur. Physicians should be especially vigilant in certain at-risk populations including children who eat paint chips or soil, spend time outside the US (particularly in Pakistan), use imported products, or have developmental delays or sickle cell disease.

Do sexual risk behaviors differ between heterosexual youth infected with HIV perinatally versus sexually?

PURPOSE: To determine if sexually active heterosexual HIV-infected 15- to 24-year-old youth have different sexual or other risk behaviors depending on whether they were infected perinatally or heterosexually. METHODS: We compared youth aged 15 to 24 years who acquired HIV perinatally or sexually and were interviewed in-person or by phone for partner services by the New York City Department of Health and Mental Hygiene. We included heterosexually active youth with at least one sexual partner of the opposite sex in the past 12 months, and excluded men who have sex with men and injection drug users. We used χ(2) tests and t tests to compare demographics, sexual risk behaviors, partner services outcomes, and viral loads. RESULTS: Both groups reported few partners (median 1, mean 2), and only 12% of partners of perinatally infected youth were previously diagnosed (18% of sexually infected youths' partners). A minority reported always using condoms. Both groups had similar rates of sexually transmitted infections and median HIV plasma RNA (perinatally infected: 5,140 copies/mL; sexually infected: 6,835 copies/mL). Despite these similarities, among tested partners not previously HIV diagnosed, none of 17 named by perinatally infected youth was newly HIV diagnosed, whereas 21% (8/39, p = .09) of those named by sexually infected youth were newly diagnosed. CONCLUSIONS: Though perinatally infected youth did not transmit HIV infection to previously undiagnosed partners, they had similar HIV-related risk behaviors to youth infected sexually who reported on risks that led to their infection. HIV prevention among HIV-infected youth remains a critical challenge.

A comparison of partner notification effectiveness in African-, Caribbean-, and United States-born HIV-infected Blacks in New York City.

HIV disproportionately affects blacks more than other groups in New York City (NYC) as well as nationally. Partner Services (PS) are a proven way to interrupt HIV transmission. In NYC, PS outcomes are worse among blacks compared to other race/ethnic groups. We compared PS outcomes by country of birth to identify opportunities for improved PS effectiveness. We assessed number of sex and needle-sharing partners elicited, notified, and HIV tested, as well as number of newly identified HIV cases and number of interviews needed to identify a new HIV case. Between July 2006 and December 2008, 1049 African Americans, 285 Caribbean-born blacks, and 168 African-born blacks were interviewed for HIV Partner Services. African Americans, Caribbean-born blacks, and African-born blacks had average age of 38, 37, and 43 years and 10.0%, 0.4%, and 0.6% reported intravenous drug use, respectively. All groups had a high proportion of cases with an AIDS-defining CD4 count at HIV diagnosis (30.8%, 34.5%, and 47.9% for African Americans, Africans, and Caribbeans, respectively). The number needed to interview to find one newly diagnosed HIV case was high for all groups (66, 57, and 56 among African Americans, Africans, and Caribbeans, respectively), indicating all had similarly low rates of new HIV case identification. NYC blacks and their partners are benefiting from current Partner Services outreach as PS did identify new HIV cases among partners from all 3 groups. However, further work is needed to improve HIV case finding from Partner Services in these groups, and additional measures to promote early diagnosis are needed.