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[Genetic markers of predisposition to an aggressive course of chronic C hepatitis].

Abdullaev, S M; Tselishcheva, Iu I; Samokhodskaia, L M; Kvasovka, V V; Ignatova, T M; Krasnova, T N; Bochkov, V N; Mukhin, N A.

Vestn Ross Akad Med Nauk ; (1): 8-13, 2007.

Article in Russian | MEDLINE | ID: mdl-17338374

ABSTRACT

The polymorphism of cytokine genes (11-1beta, IL-10, IL-6, and TGF-beta1) in patients with chronic C hepatitis and in healthy individuals was studied. The study found that the polymorphism of IL-1beta, IL-6, and TGF-beta1 may at least partially explain the genetic predisposition to an aggressive course of the disease with the development of terminal stage.

Subject(s)

DNA/genetics , Hepatitis C, Chronic/genetics , Interleukin-10/genetics , Interleukin-1beta/genetics , Interleukin-6/genetics , Polymorphism, Genetic , Transforming Growth Factor beta1/genetics , Adolescent , Adult , Disease Progression , Female , Genetic Predisposition to Disease , Hepatitis C, Chronic/blood , Hepatitis C, Chronic/complications , Humans , Interleukin-10/blood , Interleukin-1beta/blood , Interleukin-6/blood , Liver Cirrhosis/etiology , Liver Cirrhosis/pathology , Male , Middle Aged , Polymerase Chain Reaction , Prognosis , Severity of Illness Index , Transforming Growth Factor beta1/blood

ABSTRACT

Subject(s)

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