ABSTRACT
Overall 392 patients with lymphosarcoma were under observation from 1980 to 1989 at the department of childhood hematology, All-Union Cancer Research Center, USSR AMS. The patients were characterized by the moment of the disease diagnosis. During treatment, 70 patients (31%) developed disease relapses. The relapses were characterized, possible causes of their development were analyzed. The results of relapses treatment according to two programs are discussed. No increase of the survival of the patients with relapses due to the intensification of the treatment programs was noted.
Subject(s)
Lymphoma, Non-Hodgkin/therapy , Adolescent , Antineoplastic Agents/therapeutic use , Child , Child, Preschool , Humans , Interferon Type I/therapeutic use , Interferon alpha-2 , Interferon-alpha/therapeutic use , Lymphoma, Non-Hodgkin/diagnosis , Lymphoma, Non-Hodgkin/mortality , Recombinant Proteins , RecurrenceABSTRACT
Content of polyamines and extracellular DNA were studied in blood of patients with acute leukoses which did not respond to chemotherapy. Concentration of total polyamines was distinctly lower in blood of patients with acute lymphoblast and myeloblast leukoses as compared with healthy persons. Free and total polyamines were unaltered in blood of these patients after cytostatic therapy. In the patients with acute leukoses content of extracellular DNA was 2-fold higher as compared with controls. The high DNA content was maintained during the therapeutic course. Absence of any alterations in the biochemical patterns studied suggest that the patients with acute leukoses did not respond to the course of treatment used.
