ABSTRACT
The purpose of the research was to evaluate clinical course and efficiency of the method of termination of pregnancy in the first end second trimesters by means of antiprogesterone. 384 women aged 15 to 45 in the first end second trimesters of pregnancy were investigated. 300 women had an early pregnancy (range=2-7 weeks) requesting abortion. All these women first took 600 mg antiprogesterone pencroftone ("Pencroft-Fharma", Russia) and 48 hours later - 400 mkg prostaglandin misoprostol. 84 patients with gestation period ranged from 14 to 22 weeks. Their contractility utterly was caused with 400 mg pencroftone and 48 hours later with 400 mkg prostaglandin misopristol. In the first trimester completed abortion was observed in 96,7%, incomplete abortion in 1,7%; missed abortion in 2,3% cases, continuing pregnancy in 1 case. In the second trimester in the case of therapy with pencroftone and prostaglandin E1 misoprostol the clinical effect was observed in 96,4% cases. Antiprogesterone pencroftone is an effective for medical abortion during I-II trimesters of pregnancy. It is characterized by minimal risk of complications in the course and the post abortion period.
Subject(s)
Abortifacient Agents, Steroidal/administration & dosage , Abortion, Legal/methods , Abortion, Therapeutic/methods , Hormone Antagonists/administration & dosage , Mifepristone/administration & dosage , Adolescent , Adult , Female , Humans , Middle Aged , Pregnancy , Pregnancy Trimester, First/drug effects , Pregnancy Trimester, Second/drug effects , Progesterone/antagonists & inhibitorsABSTRACT
The IUD ML Cu375 was inserted, after bacteriological screening, into 620 women who were observed for 12 months. Bacterioscopy and, when needed, bacteriology of vaginal smears were performed 7 days, and 1, 3, 6 and 12 months after insertion. During the 12 months, pelvic inflammatory disease (PID) was diagnosed in 4 patients (0.6%) and sexually transmitted disease (STD) in 73 patients (11.8%). Careful selection of patients and bacteriological screening can effectively reduce the risk of bacterial contamination and subsequent development of PID.
Subject(s)
Intrauterine Devices, Copper/adverse effects , Pelvic Inflammatory Disease/etiology , Adult , Chlamydia trachomatis/isolation & purification , Escherichia coli/isolation & purification , Female , Humans , Incidence , Longitudinal Studies , Mass Screening , Pelvic Inflammatory Disease/epidemiology , Pelvic Inflammatory Disease/prevention & control , Sexually Transmitted Diseases, Bacterial/epidemiology , Sexually Transmitted Diseases, Bacterial/microbiology , Staphylococcus aureus/isolation & purificationABSTRACT
This study was conducted to evaluate the clinical performance of the Multiload Cu375 IUD in 157 healthy women, aged 18-38 years, who had regular sexual intercourse and who wished to avoid pregnancy. The period of observation was 2 years. During 24 months, pain and bleeding was noted in 7 patients (4.4%); IUD expulsion was observed in 4 cases (2.5%) and there was only 1 case (0.6%) of pregnancy. Our conclusion is that the Multiload Cu375 is an excellent method of contraception.
Subject(s)
Intrauterine Devices, Copper/standards , Adolescent , Adult , Contraceptive Devices, Female/adverse effects , Contraceptive Devices, Female/standards , Female , Georgia (Republic) , Humans , Pregnancy/statistics & numerical dataABSTRACT
One hundred and one healthy women with intrauterine devices (IUDs) were studied by echosonography; 46 women had Multiload Cu375 IUD (group I), 30 Ginetik TCu220 IUD (group II) and 25 Lippes loop IUD (group III). In groups I and II echosonography was performed 30 minutes, 30 days and 3 and 6 months following insertion. Group III was investigated only when complications developed. Echosonography showed high accuracy in detecting IUD expulsion or incorrect position, and pregnancy in the IUD wearer.
